Document Detail

Muller's ratchet and the degeneration of Y chromosomes: a simulation study.
MedLine Citation:
PMID:  18780738     Owner:  NLM     Status:  MEDLINE    
A typical pattern in sex chromosome evolution is that Y chromosomes are small and have lost many of their genes. One mechanism that might explain the degeneration of Y chromosomes is Muller's ratchet, the perpetual stochastic loss of linkage groups carrying the fewest number of deleterious mutations. This process has been investigated theoretically mainly for asexual, haploid populations. Here, I construct a model of a sexual population where deleterious mutations arise on both X and Y chromosomes. Simulation results of this model demonstrate that mutations on the X chromosome can considerably slow down the ratchet. On the other hand, a lower mutation rate in females than in males, background selection, and the emergence of dosage compensation are expected to accelerate the process.
Jan Engelstädter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-09
Journal Detail:
Title:  Genetics     Volume:  180     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-17     Completed Date:  2009-01-05     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  957-67     Citation Subset:  IM    
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
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MeSH Terms
Computer Simulation
Dosage Compensation, Genetic
Models, Genetic
Recombination, Genetic
Reproduction, Asexual / genetics
Selection, Genetic
X Chromosome
Y Chromosome / genetics*

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