Document Detail

Muller's ratchet and the degeneration of the Drosophila miranda neo-Y chromosome.
MedLine Citation:
PMID:  20215466     Owner:  NLM     Status:  MEDLINE    
Since its formation about 1.75 million years ago, the Drosophila miranda neo-Y chromosome has undergone a rapid process of degeneration, having lost approximately half of the genes that it originally contained. Using estimates of mutation rates and selection coefficients for loss-of-function mutations, we show that the high rate of accumulation of these mutations can largely be explained by Muller's ratchet, the process of stochastic loss of the least-loaded mutational class from a finite, nonrecombining population. We show that selection at nonsynonymous coding sites can accelerate the process of gene loss and that this effect varies with the number of genes still present on the degenerating neo-Y chromosome.
Vera B Kaiser; Brian Charlesworth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-09
Journal Detail:
Title:  Genetics     Volume:  185     ISSN:  1943-2631     ISO Abbreviation:  Genetics     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-09-14     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  339-48     Citation Subset:  IM    
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, United Kingdom.
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MeSH Terms
Computer Simulation
Drosophila / genetics*
Models, Genetic*
Population Density
Selection, Genetic
Y Chromosome / genetics*

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