| Muller's Nobel lecture on dose-response for ionizing radiation: ideology or science? | |
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MedLine Citation:
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PMID: 21717110 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In his Nobel Prize Lecture of December 12, 1946, Hermann J. Muller argued that the dose-response for radiation-induced germ cell mutations was linear and that there was "no escape from the conclusion that there is no threshold". However, assessment of correspondence between Muller and Curt Stern 1 month prior to his Nobel Prize Lecture reveals that Muller knew the results and implications of a recently completed study at the University of Rochester under the direction of Stern, which directly contradicted his Nobel Prize Lecture. This finding is of historical importance since Muller's Nobel Lecture gained considerable international attention and is a turning point in the acceptance of the linearity model in risk assessment for germ cell mutations and carcinogens. |
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Authors:
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Edward J Calabrese |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-30 |
Journal Detail:
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Title: Archives of toxicology Volume: - ISSN: 1432-0738 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417615 Medline TA: Arch Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Environmental Health Sciences, Department of Public Health, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, 01003, USA, edwardc@schoolph.umass.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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