Document Detail


Mullerian inhibiting substance requires its N-terminal domain for maintenance of biological activity, a novel finding within the transforming growth factor-beta superfamily.
MedLine Citation:
PMID:  8469238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mullerian inhibiting substance (MIS)/anti-Mullerian hormone is a differentiation factor that causes regression of the Mullerian duct in the developing male fetus and an apparent sex reversal of the fetal ovary when inappropriately exposed to it. The purified product is a 140-kilodalton glycoprotein composed of two identical subunits. We show that a C-terminal fragment of MIS, which shares homology with transforming growth factor-beta, causes regression of the Mullerian duct and inhibits the biosynthesis of aromatase in the fetal ovary. However, both activities are enhanced dramatically by addition of the N-terminal portion of MIS. Under conditions where potentiation occurs, the N- and C-terminal domains of MIS reassociate. These results indicate that the N-terminus of MIS, unlike that of the other members of the transforming growth factor-beta family, plays a role in maintaining the biological activity of the C-terminus.
Authors:
C A Wilson; N di Clemente; C Ehrenfels; R B Pepinsky; N Josso; B Vigier; R L Cate
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular endocrinology (Baltimore, Md.)     Volume:  7     ISSN:  0888-8809     ISO Abbreviation:  Mol. Endocrinol.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-05-11     Completed Date:  1993-05-11     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8801431     Medline TA:  Mol Endocrinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  247-57     Citation Subset:  IM    
Affiliation:
Biogen, Inc., Cambridge, Massachusetts 02142.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Mullerian Hormone
Antibodies, Monoclonal / immunology
Aromatase / biosynthesis
CHO Cells
Cattle
Cricetinae
Enzyme Induction / drug effects
Female
Fibrinolysin / metabolism
Glycoproteins*
Growth Inhibitors / chemistry*,  immunology,  pharmacology
Humans
Mullerian Ducts / drug effects*
Multigene Family*
Ovary / embryology,  enzymology
Peptide Fragments / pharmacology*
Protein Folding
Rats
Recombinant Proteins / pharmacology
Testicular Hormones / chemistry*,  immunology,  pharmacology
Transforming Growth Factor beta*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Glycoproteins; 0/Growth Inhibitors; 0/Peptide Fragments; 0/Recombinant Proteins; 0/Testicular Hormones; 0/Transforming Growth Factor beta; 80497-65-0/Anti-Mullerian Hormone; EC 1.14.14.1/Aromatase; EC 3.4.21.7/Fibrinolysin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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