Document Detail

The Muir-Torre syndrome: a disease of sebaceous and colonic neoplasms.
MedLine Citation:
PMID:  2917677     Owner:  NLM     Status:  MEDLINE    
The Muir-Torre syndrome of sebaceous neoplasms of the skin, with or without keratoacanthomas, and multiple low-grade visceral malignancies with prolonged survival is a rare disorder. Colonic polyps are frequently present, and the syndrome appears to be familial. We report 2 unrelated patients with the Muir-Torre syndrome. Each case exhibited sebaceous adenomas. Gastrointestinal findings included colonic adenocarcinomas and a tubulovillous adenoma. Although an unusual disease, the Muir-Torre syndrome requires recognition because these patients are at risk for multiple primary malignancies and may have family members also at risk.
R A Schwartz; D J Goldberg; F Mahmood; R L DeJager; W C Lambert; A Z Najem; P J Cohen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Dermatologica     Volume:  178     ISSN:  0011-9075     ISO Abbreviation:  Dermatologica     Publication Date:  1989  
Date Detail:
Created Date:  1989-03-29     Completed Date:  1989-03-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0211607     Medline TA:  Dermatologica     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  23-8     Citation Subset:  IM    
Department of Dermatology, New Jersey Medical School, Newark.
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MeSH Terms
Adenocarcinoma / genetics*
Adenoma / genetics*,  pathology
Chromosome Aberrations / genetics
Chromosome Disorders
Colorectal Neoplasms, Hereditary Nonpolyposis / genetics*
Facial Neoplasms / genetics
Genes, Dominant
Middle Aged
Neoplasms, Multiple Primary / genetics*,  pathology
Sebaceous Gland Neoplasms / genetics*,  pathology
Sebaceous Glands / pathology

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