Document Detail

Muir-Torre syndrome: case report and review of the literature.
MedLine Citation:
PMID:  21488569     Owner:  NLM     Status:  MEDLINE    
Muir-Torre syndrome (MTS), a subtype of Lynch syndrome II, presents as at least one internal malignancy associated with at least one sebaceous skin tumor. This autosomal-dominant genetic disorder is thought to arise from microsatellite instability. Although not all patients with sebaceous tumors have MTS, even a single biopsy-proven sebaceous adenoma may warrant evaluation for MTS. We report the case of a 76-year-old man with a marked family history of colon cancer; a personal history of colon cancer status post-partial resection of the colon; and multiple cutaneous neoplasms including sebaceous adenomas, sebaceous gland hyperplasia, and basal and squamous cell carcinomas. We review the literature describing MTS and highlight the important role of dermatologists and dermatopathologists in the potential early detection and initial diagnosis of this familial or hereditary colon cancer in patients presenting with cutaneous sebaceous adenomas. Correct diagnosis may be lifesaving in patients with MTS and their at-risk relatives who would benefit from earlier colonoscopy, tumor surveillance, and potential early cancer detection. Muir-Torre syndrome represents yet another dermatologic symptom of an internal disease.
Jennifer M Ang; Nili N Alai; Karina R Ritter; Lawrence A Machtinger
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cutis     Volume:  87     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-14     Completed Date:  2011-05-12     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-8     Citation Subset:  IM    
University of California, Irvine, School of Medicine, USA.
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MeSH Terms
Adenoma / complications,  pathology
Colonic Neoplasms / complications*,  pathology,  surgery
Muir-Torre Syndrome / diagnosis*,  etiology,  pathology
Sebaceous Gland Neoplasms / complications*,  pathology
Skin Neoplasms / complications,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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