Document Detail


Mugineic acid: non-selective enhancement of excitatory amino acid actions on rat central neurones.
MedLine Citation:
PMID:  3431667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of mugineic acid upon excitations induced by quisqualic acid (quis), N-methyl-D-aspartic acid (NMDA) and kainic acid (kain) on rat central neurones were examined in vivo through microiontophoretic drug administration in anaesthetized rats. Mugineic acid usually caused a non-selective enhancement of drug-induced excitations, occasionally producing direct excitation itself or increasing the rate of spontaneous discharge. Mugineic acid-induced effects were not blocked by the NMDA selective antagonist, 2-amino-5-phosphonovaleric acid (AP5).
Authors:
T Kaneko; T P Hicks; L Bauce
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropharmacology     Volume:  26     ISSN:  0028-3908     ISO Abbreviation:  Neuropharmacology     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-03-09     Completed Date:  1988-03-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1649-52     Citation Subset:  IM    
Affiliation:
Department of Medical Physiology, Faculty of Medicine, University of Calgary, Alberta, Canada.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / pharmacology*
Animals
Azetidinecarboxylic Acid / analogs & derivatives,  pharmacology*
Azetines / pharmacology*
Evoked Potentials / drug effects
Female
Male
Neurons / drug effects*,  physiology
Plants / analysis
Rats
Stimulation, Chemical
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Azetines; 2517-04-6/Azetidinecarboxylic Acid; 69199-37-7/mugineic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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