| Mucus, phlegm, and sputum in cystic fibrosis. | |
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MedLine Citation:
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PMID: 19467160 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although some clinicians still believe that cystic fibrosis (CF) lung disease is largely due to hypersecretion of very viscous mucus, it has never been demonstrated that there is mucus hypersecretion in CF and it is clear that there is almost no intact mucin (the principal polymeric component of normal mucus) in CF sputum. CF sputum has lower viscosity when compared to asthma or bronchitis sputa, but is highly tenacious and biochemically most closely resembles pus. Tenacity and lower viscosity lead to decreased cough clearance of infected phlegm, which is thought to induce a persistent inflammatory state in the airway, leading to bronchiectasis. There are many medications and devices either in use or under development that are meant to improve airway hygiene in CF by assisting with sputum expectoration. This paper discusses the scientific basis and potential mechanism of action for many of these interventions and briefly reviews the clinical evidence of their safety and effectiveness. |
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Authors:
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Bruce K Rubin |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Respiratory care Volume: 54 ISSN: 0020-1324 ISO Abbreviation: Respir Care Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-26 Completed Date: 2009-07-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7510357 Medline TA: Respir Care Country: United States |
Other Details:
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Languages: eng Pagination: 726-32; discussion 732 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem NC 27157-1081, USA. brubin@wfubmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cystic Fibrosis
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drug therapy,
metabolism* Disease Progression Expectorants / therapeutic use Humans Mucus / secretion* Respiratory Mucosa / secretion* Sputum / secretion* |
| Chemical | |
Reg. No./Substance:
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0/Expectorants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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