Document Detail

Mucous membrane pemphigoid in a patient with chronic lymphocytic leukemia.
MedLine Citation:
PMID:  15448507     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To describe a case of mucous membrane pemphigoid (MMP) with ocular manifestations in a patient subsequently diagnosed with B-cell chronic lymphocytic leukemia (CLL). METHODS: Case report and literature review. RESULTS: A 64-year-old man presented with redness and irritation of both eyes. The patient also had blistering lesions on the roof of his mouth, trunk, and buttocks as well as bilateral conjunctival ulceration and symblepharon formation. A complete blood count performed before initiating treatment of presumed mucous membrane pemphigoid revealed a markedly increased white blood cell count (83,920) with a predominance of lymphocytes. Hematologic evaluation including immunophenotyping flow cytometry resulted in the diagnosis of B-cell chronic lymphocytic leukemia. Cyclophosphamide treatment improved his MMP and decreased the white blood cell count. CONCLUSIONS: Mucous membrane pemphigoid has been reported in association with a variety of nonhematologic malignancies. This case suggests that mucous membrane pemphigoid may also occur in B-cell CLL and supports the concept that autoantibodies play a role in the pathogenesis of this cicatricial conjunctival disease.
Rajeev K Seth; Grant W Su; Stephen C Pflugfelder
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Cornea     Volume:  23     ISSN:  0277-3740     ISO Abbreviation:  Cornea     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-27     Completed Date:  2004-12-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  740-3     Citation Subset:  IM    
Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA.
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MeSH Terms
Conjunctival Diseases / etiology*,  pathology
Cyclophosphamide / therapeutic use
Immunosuppressive Agents / therapeutic use
Leukemia, Lymphocytic, Chronic, B-Cell / complications*
Middle Aged
Pemphigoid, Benign Mucous Membrane / complications*,  drug therapy
Ulcer / etiology*,  pathology
Reg. No./Substance:
0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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