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Mucosal leishmaniasis with primary oral involvement: a case-series and a review of the literature.
MedLine Citation:
PMID:  24939442     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To analyze retrospectively a case series of primary oral leishmaniasis and to review the literature on head-neck primary mucosal leishmaniasis in immunocompetent patients.
SUBJECTS AND METHODS: A PUBMED search was carried out from 1950 to 2013. Clinical records of patients with primary head-neck mucosal manifestations of leishmaniasis were analyzed. In addition, clinical records between 2001-2012 of patients with primary oral manifestations were collected in two independent hospitals.
RESULTS: Our multicenter case series revealed 7 patients with oral leishmaniasis. The most commonly affected site was the tongue (4 patients, 57%) and the most common clinical presentation was an exophytic lesion (6 patients, 85%). The literature review showed 11 reports published between 2005-2013,describing 13 patients (100% male) affected by head-neck primary mucosal leishmaniasis (54% laryngeal, 31% oral, 23% pharyngeal, and 15% endonasal). The most common clinical presentation was an exophytic lesion (69%).
CONCLUSIONS: The literature analysis revealed that in immunocompetent patients the oral mucosa is the second most frequently affected site of the head and neck region. In the oral cavity the tongue is the most affected site. Diagnosis of oral leishmaniasis represents a challenge but must be considered in any differential diagnosis of exophytic lesions of oral mucosa. This article is protected by copyright. All rights reserved.
Mignogna Michele Davide; Celentano Antonio; Leuci Stefania; Cascone Marco; Adamo Daniela; Ruoppo Elvira; Favia Gianfranco
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-17
Journal Detail:
Title:  Oral diseases     Volume:  -     ISSN:  1601-0825     ISO Abbreviation:  Oral Dis     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508565     Medline TA:  Oral Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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