Document Detail


Mucosal immunology of tolerance and allergy in the gastrointestinal tract.
MedLine Citation:
PMID:  22447352     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mucosal immune system typically exists in a state of active tolerance to food antigens and commensal bacteria. Tolerance to food proteins is induced in part by dendritic cells residing in the intestinal mucosa and implemented by regulatory T cells. Food allergy occurs when immune tolerance is disrupted and a sensitizing immune response characterized by food-specific IgE production occurs instead. Experimental food allergy in mice requires use of adjuvant or exploitation of alternate routes of sensitization to induce allergic sensitization, and can aid in understanding the mechanisms of sensitization to food allergens and the pathophysiology of gastrointestinal manifestations of food allergy. Recent work in the understanding of mucosal immunology of tolerance and allergy in the gastrointestinal tract will be discussed.
Authors:
Lauren Steele; Lloyd Mayer; M Cecilia Berin
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunologic research     Volume:  54     ISSN:  1559-0755     ISO Abbreviation:  Immunol. Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-10-17     Completed Date:  2013-03-07     Revised Date:  2013-11-07    
Medline Journal Info:
Nlm Unique ID:  8611087     Medline TA:  Immunol Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  75-82     Citation Subset:  IM    
Affiliation:
Mount Sinai School of Medicine, Immunology Institute, New York, NY 10029, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens / immunology
Food Hypersensitivity / immunology*
Humans
Immune Tolerance*
Intestinal Mucosa / immunology*
Grant Support
ID/Acronym/Agency:
AI044236/AI/NIAID NIH HHS; P01 DK072201/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antigens
Comments/Corrections

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