Document Detail


Mucosal immunity and poliovirus vaccines: Impact on wild poliovirus infection and transmission.
MedLine Citation:
PMID:  21896299     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Since the resolution of the World Assembly in 1988 to eradicate polio globally, substantial progress toward this target has been achieved, but the final goal remains elusive. India and other tropical developing countries present a unique challenge because of the much lower oral poliovirus vaccine (OPV) immunogenicity compared to industrialized countries, both in terms of humoral and mucosal immunity. To overcome this challenge, further research is needed to elucidate the causes for the suboptimal OPV immunogenicity, better defining the optimal vaccine schedules and delivery strategies, developing and evaluating adjuvants to boost OPV immunogenicity, and improving the methods for directly measuring mucosal immunity.
Authors:
Hiromasa Okayasu; Roland Sutter; Cecil Czerkinsky; Pearay L Ogra
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-3
Journal Detail:
Title:  Vaccine     Volume:  -     ISSN:  1873-2518     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 World Health Organization. Published by Elsevier Ltd.. All rights reserved.
Affiliation:
Polio Eradication Initiative, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland.
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