Document Detail

Mucosal immunity in primary glomerulonephritis: II. Study of the serum IgA subclass repertoire to food and airborne antigens.
MedLine Citation:
PMID:  1766494     Owner:  NLM     Status:  MEDLINE    
IgA specific for 7 food and 6 airborne antigens were sought in the serum of 30 adult patients with IgA mesangial nephropathy (IgA GN), 23 with membranous nephropathy (MGN), 20 with idiopathic nephrotic syndrome (INS), 11 with membranoproliferative GN (MPGN) and 22 healthy controls by means of an enzyme-linked immunoassay. The IgA subclass was determined using monoclonal antibodies. Increased levels of IgA specific for gliadin, bovine serum albumin (BSA), ovalbumin, lysozyme and alpha-lactalbumin were found in IgA GN, while increased levels of IgA to BSA, ovalbumin, lysozyme and alpha-lactalbumin were observed in MGN; IgA specific for alpha-lactalbumin were increased in INS, and MPGN patients had reduced levels of IgA to BSA and increased levels of IgA to beta-lactoglobulin and alpha-lactalbumin. These specific IgA to food antigens were restricted to the IgA1 subclass. Patients with IgA GN had significantly increased levels of IgA specific for Dermatophagoides pteronyssinus (DP) and Dactil while the MGN group showed increased levels of IgA specific for DP, feathers, Dactil and mold. INS patients had increased levels of IgA specific for DP, feathers, Dactil, mold and dog hairs, while MPGN patients had increased levels of IgA specific for feathers, Dactil, dog hairs and mold. All these specific IgA to airborne antigens were restricted to the IgA1 subclass. Patients with the four types of primary glomerulonephritis had decreased IgA specific for cat hairs which were of both the IgA1 and IgA2 subclasses. We conclude that anomalies of the IgA repertoire to environmental antigens are also encountered in primary glomerulonephritis other than IgA GN.
G Rostoker; M Petit-Phar; S Delprato; H Terzidis; P Lang; J M Dubert; B Weil; G Lagrue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephron     Volume:  59     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1991  
Date Detail:
Created Date:  1992-02-19     Completed Date:  1992-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  561-6     Citation Subset:  IM    
Department of Nephrology, INSERM U-139, Centre Claude-Bernard, Hôpital Henri-Mondor, Créteil, France.
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MeSH Terms
Antigen-Antibody Complex / blood
Glomerulonephritis, IGA / immunology*
Glomerulonephritis, Membranoproliferative / immunology
Glomerulonephritis, Membranous / immunology
Immunoglobulin A / classification*
Mucous Membrane / immunology
Nephrotic Syndrome / immunology
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Antigens; 0/Immunoglobulin A

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