Document Detail

Mucosal changes in gastric ulceration and their response to carbenoxolone sodium.
MedLine Citation:
PMID:  810394     Owner:  NLM     Status:  MEDLINE    
The epithelial differences between the normal stomach (six subjects) and 47 patients with gastric ulcers were compared. The concentrations of intraepithelial lymphocytes and polymorphonuclear leucocytes in lesser curve and prepyloric gastirc ulcers were compared, the effect of treatment with carbenoxolone sodium was studied. There is a statistically significant reduction in the total number of intraepithelial polymorphonuclear leucocytes before and after successful treatment with carbenoxolone sodium. There is also a statistically significant decrease in the quantity of intraepithelial lymphocytes in those patients with lesser curve gastric ulcers successfully treated with carbenoxolone sodium, whereas there is a significant increase in those patients with prepyloric gastric ulcers successfully treated and those patients in whom treatment failed. The value of counts of migrating white blood cells as a method of objectively assessing the effect of healing drugs upon the gastric mucosa is discussed. Pseudomonas aeruginosa was found in many specimens obtained, and evidence is presented that this was not a contaminant. Carbenoxolone appeared to increase the amount of mucus but had little effect upon the number of bacteria found. The possible contribution of Pseudomonas aeruginosa to gastric ulceration is discussed.
H W Steer; D G Colin-Jones
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Gut     Volume:  16     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1976-01-17     Completed Date:  1976-01-17     Revised Date:  2010-09-03    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  590-7     Citation Subset:  AIM; IM    
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MeSH Terms
Carbenoxolone / pharmacology,  therapeutic use*
Cell Movement / drug effects
Clinical Trials as Topic
Gastric Mucosa / drug effects,  microbiology,  pathology*
Leukocytes / drug effects
Mucus / drug effects
Phagocytosis / drug effects
Pseudomonas aeruginosa / isolation & purification
Stomach Ulcer / drug therapy,  microbiology,  pathology*
Triterpenes / therapeutic use*
Reg. No./Substance:
0/Triterpenes; 5697-56-3/Carbenoxolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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