Document Detail


Mucosal blood flow in erosive duodenitis.
MedLine Citation:
PMID:  8228079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erosive duodenitis is a clinical entity whose pathogenesis is still obscure. Acid secretion is mostly normal, while the possible role of vascular factors has been suggested. We measured mucosal blood flow by means of laser Doppler velocimetry during endoscopy in the duodenal bulb of 10 subjects with erosive duodenitis, 10 duodenal ulcer patients, and 10 healthy controls. Duodenal blood flow in erosive duodenitis was significantly reduced (p < 0.001) compared with controls, whereas no changes were detected in duodenal ulcer. Reassessment of mucosal blood flow after a 6-week treatment with ranitidine failed to show any increase in the perfusion values even in patients with endoscopic healing. Our results suggest that impaired mucosal blood flow is a primary factor in the pathogenesis of chronic duodenal erosions.
Authors:
M Guslandi; M Sorghi; A Foppa; A Tittobello
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  17     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-12-16     Completed Date:  1993-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  201-3     Citation Subset:  IM    
Affiliation:
Gastroenterology Unit, S. Raffaele Hospital, University of Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Duodenal Ulcer / physiopathology
Duodenitis / drug therapy,  etiology,  physiopathology*
Duodenoscopy
Female
Humans
Intestinal Mucosa / blood supply*
Laser-Doppler Flowmetry
Male
Middle Aged
Ranitidine / therapeutic use
Regional Blood Flow / physiology
Time Factors
Chemical
Reg. No./Substance:
66357-35-5/Ranitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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