Document Detail


Mucosal biomarkers of colorectal cancer risk do not increase at 6 months following sleeve gastrectomy, unlike gastric bypass.
MedLine Citation:
PMID:  23625552     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: We tested the hypothesis that sleeve gastrectomy (SG) is not associated with an increase in mucosal CRC biomarkers, unlike Roux-en-Y gastric bypass (RYGB). Design and Methods: Rectal mucosa, blood and urine were obtained from morbidly obese patients (n=23) before and after (median 28 months) SG, as well as from non-obese controls (n=20). Rectal epithelial cell mitosis and apoptosis, crypt size/fission and pro-inflammatory gene expression were measured, as well as systemic inflammatory biomarkers, including C-reactive protein (CRP). Results: The mean pre-operative body mass index in SG patients was 65.7 Kg/m(2) (24.7 Kg/m(2) in controls). Mean excess weight loss post-SG was 38.2%. There was a significant increase in mitosis frequency, crypt size and crypt fission (all p<0.01) in SG patients versus controls, as well as evidence of a chronic inflammatory state (raised CRP and mononuclear cell p65 NFĸB binding), but there was no significant change in these biomarkers after SG, except CRP reduction. Macrophage migration inhibitory factor (MIF) mRNA levels were increased by 39% post-SG (p=0.038). Conclusions: Mucosal biomarkers of CRC risk do not increase at 6 months following SG, unlike RYGB. Biomarkers of rectal crypt proliferation and systemic inflammation are increased in morbidly obese patients compared with controls.
Authors:
Prashant Kant; Sarah L Perry; Simon P Dexter; Amanda D Race; Paul M Loadman; Mark A Hull
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-27
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  -     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 The Obesity Society.
Affiliation:
Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds LS9 7TF, United Kingdom.
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