Document Detail


Mucosal associated invariant T cells: don't forget your vitamins.
MedLine Citation:
PMID:  23208418     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T lymphocytes express clonal receptors, called T cell receptors (TCRs), which specifically recognize antigens presented in combination with major histocompatibility molecules (MHC). To date, T cell antigens can be broadly categorized into two classes: peptides and lipids. A recent paper published in Nature by Kjer-Nielsen and colleagues reveals that a unique population of T lymphocytes expresses TCRs that recognize a completely new and unexpected class of antigens, vitamin metabolites.
Authors:
Mary H Young; Laurent Gapin
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Publication Detail:
Type:  Comment; Journal Article     Date:  2012-12-04
Journal Detail:
Title:  Cell research     Volume:  23     ISSN:  1748-7838     ISO Abbreviation:  Cell Res.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-01     Completed Date:  2013-09-13     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  9425763     Medline TA:  Cell Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  460-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Folic Acid / metabolism*
Histocompatibility Antigens Class I / chemistry*,  immunology*
Humans
Pterins / chemistry*,  immunology*
T-Lymphocytes / immunology*
Grant Support
ID/Acronym/Agency:
R01 AI092108/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Histocompatibility Antigens Class I; 0/Pterins; 935E97BOY8/Folic Acid
Comments/Corrections
Comment On:
Nature. 2012 Nov 29;491(7426):717-23   [PMID:  23051753 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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