Document Detail


Mucosal vaccines for biodefense.
MedLine Citation:
PMID:  21461982     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bioterrorism is the deliberate release of biological toxins, pathogenic viruses, bacteria, parasites, or other infectious agents into the public sphere with the objective of causing panic, illness, and/or death on a local, regional, or possibly national scale. The list of potential biological agents compiled by the Centers for Disease Control and Prevention is long and diverse. However, a trait common to virtually all the potential bioterrorism agents is the fact that they are likely to be disseminated by either aerosol or in food/water supplies with the intention of targeting the mucosal surfaces of the respiratory or gastrointestinal tracts, respectively. In some instances, inhalation or ingestion would mimic the natural route by which humans are exposed to these agents. In other instances, (e.g., the inhalation of a toxin is normally associated with food borne illness), it would represent an unnatural route of exposure. For most potential bioterrorism agents, the respiratory or gastrointestinal mucosa may simply serve as a route of entry by which they gain access to the systemic compartment where intoxication/replication occurs. For others, however, the respiratory or gastrointestinal mucosa is the primary tissue associated with pathogenesis, and therefore, the tissue for which countermeasures must be developed.
Authors:
N J Mantis; L A Morici; C J Roy
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current topics in microbiology and immunology     Volume:  354     ISSN:  0070-217X     ISO Abbreviation:  Curr. Top. Microbiol. Immunol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-01-11     Completed Date:  2012-04-24     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  0110513     Medline TA:  Curr Top Microbiol Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  181-95     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Bioterrorism / prevention & control*
Humans
Infection / immunology,  microbiology,  virology
Infection Control*
Mucous Membrane / immunology*
United States
Vaccines / administration & dosage,  immunology*
Grant Support
ID/Acronym/Agency:
R03 AI097688/AI/NIAID NIH HHS; U01AI070624/AI/NIAID NIH HHS; U01AI075509/AI/NIAID NIH HHS; U54AI057158/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer dise...
Next Document:  Changes in water level, land use, and hydrological budget in a semi-permanent playa lake, Southwest ...