Document Detail


Mucosal melanomas: a case-based review of the literature.
MedLine Citation:
PMID:  20571149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mucosal melanoma is a rare cancer that is clearly distinct from its cutaneous counterpart in biology, clinical course, and prognosis. Recent studies have shown important differences in the frequencies of various genetic alterations in different subtypes of melanoma. Activating mutations in the c-KIT gene are detected in a significant number of patients with mucosal melanoma. This observation has resulted in the initiation of several clinical trials aimed at exploring the role of receptor tyrosine kinases that inhibit c-KIT in this patient population. We herein present a comprehensive literature review of mucosal melanoma along with case vignettes of a number of pertinent cases. We further discuss melanomas of the head and neck, the female genital tract, and the anorectum, which are the three most common sites of mucosal melanoma, with a particular focus on the diagnostic, prognostic, and therapeutic data available in the literature.
Authors:
Nagashree Seetharamu; Patrick A Ott; Anna C Pavlick
Related Documents :
9056649 - Lymphangioma-like variant of kaposi's sarcoma: clinicopathologic study of seven cases w...
1098379 - Pathology of primary reticulum cell sarcoma of the human central nervous system.
2161339 - Malignant fibrous primary histiocytoma of the recto-vaginal septum.
992649 - Embryonal rhabdomyosarcoma (sarcoma botryoides) of the common bile duct: a case report.
16972949 - Cd99 immunoreactivity in atypical fibroxanthoma and pleomorphic malignant fibrous histi...
7805409 - Unilateral pseudo-kaposi's sarcoma (bluefarb-stewart type).
21889809 - An evaluation of foot-and-mouth disease outbreak reporting in mainland south-east asia ...
1919819 - A case of glutaric acidemia type ii (severe multiple acyl-coa dehydrogenation disorder)...
3856409 - Extraction of four second molars.
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-06-22
Journal Detail:
Title:  The oncologist     Volume:  15     ISSN:  1549-490X     ISO Abbreviation:  Oncologist     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-29     Completed Date:  2010-12-14     Revised Date:  2012-09-18    
Medline Journal Info:
Nlm Unique ID:  9607837     Medline TA:  Oncologist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  772-81     Citation Subset:  IM    
Affiliation:
NYU Cancer Institute, 160E 34th Street, New York, New York 10016, USA. anna.pavlick@nyumc.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Female
Genital Neoplasms, Female*
Head and Neck Neoplasms*
Humans
Male
Melanoma* / diagnosis,  therapy
Middle Aged
Mucous Membrane / pathology*
Neoplasm Staging
Prognosis
Rectal Neoplasms*
Skin Neoplasms* / diagnosis,  therapy
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Home and community composting for on-site treatment of urban organic waste: perspective for Europe a...
Next Document:  Global climate change and tree nutrition: effects of elevated CO2 and temperature.