Document Detail

Mucosal melanomas: a case-based review of the literature.
MedLine Citation:
PMID:  20571149     Owner:  NLM     Status:  MEDLINE    
Mucosal melanoma is a rare cancer that is clearly distinct from its cutaneous counterpart in biology, clinical course, and prognosis. Recent studies have shown important differences in the frequencies of various genetic alterations in different subtypes of melanoma. Activating mutations in the c-KIT gene are detected in a significant number of patients with mucosal melanoma. This observation has resulted in the initiation of several clinical trials aimed at exploring the role of receptor tyrosine kinases that inhibit c-KIT in this patient population. We herein present a comprehensive literature review of mucosal melanoma along with case vignettes of a number of pertinent cases. We further discuss melanomas of the head and neck, the female genital tract, and the anorectum, which are the three most common sites of mucosal melanoma, with a particular focus on the diagnostic, prognostic, and therapeutic data available in the literature.
Nagashree Seetharamu; Patrick A Ott; Anna C Pavlick
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-06-22
Journal Detail:
Title:  The oncologist     Volume:  15     ISSN:  1549-490X     ISO Abbreviation:  Oncologist     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-29     Completed Date:  2010-12-14     Revised Date:  2012-09-18    
Medline Journal Info:
Nlm Unique ID:  9607837     Medline TA:  Oncologist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  772-81     Citation Subset:  IM    
NYU Cancer Institute, 160E 34th Street, New York, New York 10016, USA.
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MeSH Terms
Aged, 80 and over
Genital Neoplasms, Female*
Head and Neck Neoplasms*
Melanoma* / diagnosis,  therapy
Middle Aged
Mucous Membrane / pathology*
Neoplasm Staging
Rectal Neoplasms*
Skin Neoplasms* / diagnosis,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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