Document Detail

Mucosa-associated lymphoid tissue lymphoma of the esophagus: case report and review of the literature.
MedLine Citation:
PMID:  15143908     Owner:  NLM     Status:  MEDLINE    
We report the histomorphologic and immunohistochemical features of another case of mucosa-associated lymphoid tissue (MALT) lymphoma arising from the esophagus and discuss the problems of differential diagnosis. The patient was a 49-year-old man, who had no gastrointestinal symptoms. On endoscopy, a smooth-surfaced, semibulbous lesion was found 36 cm from the incisors. We performed radical resection of this submucosal tumor with video-assisted thoracoscopic surgery for the purpose of diagnosis and treatment. The immunophenotype of the centrocyte-like-cells was CD20+, BCL2+, CD5-, CD10-, CD23- CD45RO- and cyclin D1-. Diffuse immunostaining of bcl-2 was detected in the nuclei of the tumor cells without lymph follicles. Southern blotting analyses of the IgH gene detected a single dominant band indicative of a clonal IgH rearrangement. From the pathological, immunohistochemical, and molecular biological features we concluded that the tumor was a MALT lymphoma. Only three cases of primary esophageal MALT lymphoma have been reported to date. On the basis of the present case and the three previously reported cases, we suggest that MALT lymphoma of the esophagus is usually an elevated type. The spectrum of sites in which gastrointestinal MALT lymphoma occurs should be expanded to include the esophagus.
Tatsuya Miyazaki; Hiroyuki Kato; Norihiro Masuda; Masanobu Nakajima; Ryokuhei Manda; Minoru Fukuchi; Katsuhiko Tsukada; Masaru Kojima; Takashi Nakajima; Hiroyuki Kuwano
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  51     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2004 May-Jun
Date Detail:
Created Date:  2004-05-17     Completed Date:  2004-07-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  750-3     Citation Subset:  IM    
Department of Surgery I, Gunma University Faculty of Medicine, Maebashi Gunma, Japan.
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MeSH Terms
Esophageal Neoplasms* / diagnosis,  surgery
Lymphoma, B-Cell, Marginal Zone* / diagnosis,  surgery
Middle Aged

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