| Mucociliary transport in allergic patients with antigen-induced bronchospasm. | |
| | |
MedLine Citation:
|
PMID: 101106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Tracheal mucous velocity (TMV) and respiratory mechanics were measured in asymptomatic asthmatic patients with ragweed hypersensitivity before and after inhalation of specific antigen, and with or without cromolyn sodium pretreatment. TMV was measured radiographically, and the airway response to bronchial provocation was monitored by measurements of forced expiratory volume in one sec and specific airway conductance. TMV was significantly less (6.3 +/- 2.3 mm per min, mean +/- SD) in the 6 asymptomatic asthmatic patients than in 7 normal subjects (11.6 +/- 3.6 mm per min, mean +/- SD). In the asthmatic patients, mean TMV diminished to 72 per cent of baseline immediately after bronchial provocation when specific airway conductance was decreased to 65 per cent of baseline or less, with a further decrease in TMV to 47 per cent of baseline after one hour, at which time respiratory mechanics had returned to baseline values. Pretreatment with cromolyn sodium prevented the decrease in TMV after bronchial provocation. We concluded that in asymptomatic patients with allergic asthma, (1) baseline TMV is impaired, (2) inhalation of specific antigen causes a marked decrease in TMV independent of the degree of bronchospasm, and (3) the decrease in TMV may be related to the release of chemical mediators. |
| | |
Authors:
|
R J Mezey; M A Cohn; R J Fernandez; A J Januszkiewicz; A Wanner |
Related Documents
:
|
16340706 - Effects of nitrogen dioxide on allergic airway responses in subjects with asthma. 18671726 - Histamine-induced progression from heterologous to homologous desensitization of contra... 7363566 - Practical importance of a preceding full inhalation or exhalation upon the measurement ... 22620496 - Hydration, sweat and thermoregulatory responses to professional football training in th... 18823806 - Methodological aspects of crossover and maximum fat-oxidation rate point determination. 16340706 - Effects of nitrogen dioxide on allergic airway responses in subjects with asthma. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American review of respiratory disease Volume: 118 ISSN: 0003-0805 ISO Abbreviation: Am. Rev. Respir. Dis. Publication Date: 1978 Oct |
Date Detail:
|
Created Date: 1978-12-27 Completed Date: 1978-12-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370523 Medline TA: Am Rev Respir Dis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 677-84 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aerosols Airway Resistance Allergens / administration & dosage Asthma / physiopathology* Bronchial Spasm / physiopathology* Cilia* Cromolyn Sodium / pharmacology Dose-Response Relationship, Immunologic Female Forced Expiratory Volume Humans Male Middle Aged Pulmonary Ventilation Respiration Rhinitis, Allergic, Seasonal / physiopathology* Spirometry Trachea / physiopathology* |
| Chemical | |
Reg. No./Substance:
|
0/Aerosols; 0/Allergens; 15826-37-6/Cromolyn Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capac...
Next Document: Primary antituberculous drug resistance in Hawaii, 1957 to 1977.