| Muckle-Wells syndrome/neonatal-onset multisystem inflammatory disease overlap associated with myelodysplasia and cerebrovascular accident. | |
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MedLine Citation:
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PMID: 20456407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a patient with overlapping clinical features of Muckle-Wells syndrome and neonatal-onset multisystem inflammatory disease with an absence of mutation in exon 3 of the CIAS1 ⁄ PYPAF1 ⁄ NALP3 gene. Myelodysplasia and cerebrovascular accident were additional features in this patient, which to our knowledge have not been previously described in association with these disorders. The urticarial rash, myelodysplasia and raised inflammatory markers responded to treatment with the interleukin-1 receptor antagonist, anakinra. |
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Authors:
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V Madan; H Kingston; L A Jamieson; N Goyal; R Ead |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical and experimental dermatology Volume: 35 ISSN: 1365-2230 ISO Abbreviation: Clin. Exp. Dermatol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-21 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7606847 Medline TA: Clin Exp Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 752-5 Citation Subset: IM |
Affiliation:
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Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester, UK. vishalmadan@doctors.org.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cryopyrin-associated Periodic Syndromes / diagnosis*, drug therapy Female Humans Interleukin 1 Receptor Antagonist Protein / therapeutic use Myelodysplastic Syndromes / diagnosis*, drug therapy Stroke / diagnosis*, drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Interleukin 1 Receptor Antagonist Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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