Document Detail


Mucinous tumors of the ovary: current thoughts on diagnosis and management.
MedLine Citation:
PMID:  24777667     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Mucinous tumors of the ovary represent a spectrum of neoplastic disorders, including benign mucinous cystadenoma, pseudomyxoma peritonei, mucinous tumors of low malignant potential (borderline), and invasive mucinous ovarian carcinoma. These tumors are related closely to each other and are distinct from other histologic subtypes of epithelial ovarian neoplasms from a clinical, histologic, and molecular standpoint. A continuum appears to be present from benign to borderline to malignant, which is different from other types of epithelial ovarian cancer. Mutational profiles are also distinct, as KRAS mutations are common, but p53 and BRCA mutations are infrequent. These characteristics lead to specific biologic behavior and guide both clinical management and research efforts in patients with mucinous ovarian tumors.
Authors:
Jubilee Brown; Michael Frumovitz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current oncology reports     Volume:  16     ISSN:  1534-6269     ISO Abbreviation:  Curr Oncol Rep     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-04-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888967     Medline TA:  Curr Oncol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  389     Citation Subset:  IM    
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