| Mucinous carcinoma of the duodenum associated with hereditary nonpolyposis colorectal cancer: report of a case. | |
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MedLine Citation:
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PMID: 17123147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We herein report a rare case of primary mucinous carcinoma of the duodenum associated with hereditary nonpolyposis colorectal cancer (HNPCC). A 50-year-old man known to have HNPCC based on the Amsterdam criteria I was admitted because of the presence of a duodenal tumor. Duodenoscopy revealed an ulcerated tumor in the posterior wall of the second portion of the duodenum and the malignancy was confirmed by a biopsy. He underwent a pylorus-preserving pancreaticoduodenectomy with a regional lymph node dissection. The histological diagnosis was mucinous carcinoma of the duodenum with lymph node metastasis. High-frequency microsatellite instability (MSI-H) was identified in both the colon and a duodenal specimen based on a microsatellite assay. A germline mutation in the hMSH2 gene was also identified. Even though extracolonic malignancies are associated with HNPCC, duodenal cancer is nevertheless very rare, and only two cases have been reported over the past 20 years. The present case is therefore only the third such case and the patient is herein described with a brief review of the literature. |
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Authors:
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Toshihiko Yagyu; Tsukasa Aihara; Michinori Murayama; Shoichi Kikuchi; Eisyu Nakamura; Kazuo Hase; Kazuo Hatsuse; Kazuo Tamura; Hidetaka Mochizuki |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-12-25 |
Journal Detail:
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Title: Surgery today Volume: 36 ISSN: 0941-1291 ISO Abbreviation: Surg. Today Publication Date: 2006 |
Date Detail:
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Created Date: 2006-11-23 Completed Date: 2007-11-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204360 Medline TA: Surg Today Country: Japan |
Other Details:
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Languages: eng Pagination: 1129-32 Citation Subset: IM |
Affiliation:
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Second Department of Surgery, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya-shi, Hyogo 663-8501, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma, Mucinous
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complications*,
diagnosis,
surgery Colorectal Neoplasms, Hereditary Nonpolyposis / complications*, diagnosis Diagnosis, Differential Duodenal Neoplasms / complications*, diagnosis, surgery Endoscopy, Gastrointestinal Endosonography Follow-Up Studies Humans Male Middle Aged Pancreaticoduodenectomy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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