Document Detail

Mucin histochemistry of the columnar epithelium of the oesophagus: a retrospective study.
MedLine Citation:
PMID:  7276206     Owner:  NLM     Status:  MEDLINE    
Reflux oesophagitis may be accompanied by replacement of squamous epithelium by columnar epithelium (Barrett's oesophagus). The columnar epithelium may resemble either gastric or intestinal mucosa, though ultrastructural and histochemical studies indicate that the intestinal type does not necessarily resemble normal small intestine. Twenty-two malignant and 10 benign oesophageal specimens were examined histologically and by mucin histochemistry in an attempt to classify the various types of columnar epithelium. An incompletely differentiated variant of intestinal metaplasia secreting sulphomucins was associated with well but not poorly differentiated adenocarcinomas (p less than 0.02; Fisher's exact test). Similar findings have been described in the stomach and incomplete intestinal metaplasia may be related to disorders of growth and differentiation described in other sites such as the colon. These observations may help in the interpretation of oesophageal biopsies, possibly permitting identification of patients at risk of developing oesophageal adenocarcinoma.
J R Jass
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  34     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-11-24     Completed Date:  1981-11-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  866-70     Citation Subset:  AIM; IM    
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MeSH Terms
Adenocarcinoma / metabolism*
Epithelium / metabolism
Esophageal Neoplasms / metabolism*
Esophagus / metabolism*
Metaplasia / metabolism
Mucins / metabolism*
Retrospective Studies
Reg. No./Substance:
0/Mucins; 0/sulfomucin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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