Document Detail


Mucin gene expression in cardiac myxoma.
MedLine Citation:
PMID:  15117101     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myxoma is the most common benign neoplasm of the heart. This work is the first to present an unusual left atrium and mitral valve cardiac myxoma which cannot be completely resected. This cardiac myxoma was also associated with abundant mucopolysaccharidic matrix, including mucin. Mucin gene expression is cell- and tissue-specific, with variations during cell differentiation and inflammation, and is altered during carcinogenesis. The expression of mucin genes in cardiac myxoma has never been elucidated previously. Detailed immunohistochemical analysis of MUC1, MUC2 and MUC5AC has been performed in this left atrium and mitral valve myxoma. Notably, the expressions of mucins in cardiac myxoma must be further evaluated.
Authors:
P H Chu; S M Jung; C H Yeh; T S Yeh; C L Wang
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of clinical practice     Volume:  58     ISSN:  1368-5031     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-30     Completed Date:  2004-07-06     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  306-9     Citation Subset:  IM    
Affiliation:
The Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan. pchu@adm.cgmh.org.tw
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MeSH Terms
Descriptor/Qualifier:
Aged
Female
Gene Expression
Heart Atria
Heart Neoplasms / metabolism*,  ultrasonography
Humans
Mitral Valve
Mucins / genetics,  metabolism*
Myxoma / metabolism*,  ultrasonography
Neoplasm Proteins / metabolism
Chemical
Reg. No./Substance:
0/Mucins; 0/Neoplasm Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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