Document Detail

MuLV-insertional mutagenesis of c-myb and Mml1 in a murine model for promonocytic leukemia.
MedLine Citation:
PMID:  9209355     Owner:  NLM     Status:  MEDLINE    
Analysis of retroviral integration sites in MuLV-induced promonocytic leukemias has determined that two genetic loci, c-myb and Mml1, can contribute to disease development but not in the same leukemia. Recent studies aimed at understanding the function of Myb in leukemia development have focused on the consequences of ectopic Myb expression on monocytic and granulocytic differentiation in vitro. In all instances Myb was shown to block growth arrest but not commitment to differentiation, a result which is consistent with observed effects of Myb in leukemia development. No effect of Myb protein truncation was observed in these studies although similar truncations are produced as a result of insertional mutagenesis. Common integration site, Mml1, was recently identified and mapped to mouse chromosome 10 within 1cM of c-myb. Despite its linkage to c-myb, Myb mRNA and protein expression appear to be unaffected in leukemias with Mml1 integrations.
J Bies; R Koller; B Hoffman; A Amanullah; B Mock; L Wolff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Leukemia     Volume:  11 Suppl 3     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-08-07     Completed Date:  1997-08-07     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  247-50     Citation Subset:  IM    
Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892-4255, USA.
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MeSH Terms
Cell Differentiation
Cell Line
Chromosome Mapping*
Disease Models, Animal
Granulocytes / cytology
Leukemia Virus, Murine / genetics*
Leukemia, Myeloid / genetics*,  virology*
Macrophages / cytology
Monocytes / cytology
Mutagenesis, Insertional
Proto-Oncogene Proteins / biosynthesis,  genetics*
Proto-Oncogene Proteins c-myb
Trans-Activators / biosynthesis,  genetics*
Virus Integration*
Reg. No./Substance:
0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-myb; 0/Trans-Activators

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