Document Detail

Mu-opioid receptors and dietary protein stimulate a gut-brain neural circuitry limiting food intake.
MedLine Citation:
PMID:  22771138     Owner:  NLM     Status:  MEDLINE    
Intestinal gluconeogenesis is involved in the control of food intake. We show that mu-opioid receptors (MORs) present in nerves in the portal vein walls respond to peptides to regulate a gut-brain neural circuit that controls intestinal gluconeogenesis and satiety. In vitro, peptides and protein digests behave as MOR antagonists in competition experiments. In vivo, they stimulate MOR-dependent induction of intestinal gluconeogenesis via activation of brain areas receiving inputs from gastrointestinal ascending nerves. MOR-knockout mice do not carry out intestinal gluconeogenesis in response to peptides and are insensitive to the satiety effect induced by protein-enriched diets. Portal infusions of MOR modulators have no effect on food intake in mice deficient for intestinal gluconeogenesis. Thus, the regulation of portal MORs by peptides triggering signals to and from the brain to induce intestinal gluconeogenesis are links in the satiety phenomenon associated with alimentary protein assimilation.
Celine Duraffourd; Filipe De Vadder; Daisy Goncalves; Fabien Delaere; Armelle Penhoat; Bleuenn Brusset; Fabienne Rajas; Dominique Chassard; Adeline Duchampt; Anne Stefanutti; Amandine Gautier-Stein; Gilles Mithieux
Related Documents :
2380848 - Feeding behavior of 6- to 12-month-old infants: assessment and sources of parental info...
19036988 - The melanocortin-3 receptor is required for entrainment to meal intake.
1423738 - Pinealectomy decelerates the circadian food intake rhythm of cervically sympathectomize...
7233078 - 'partial' sham feeding releases gastrin in normal human subjects.
1946708 - Influence of glucose, medium- and long-chain triglyceride gastric loads and forced exer...
18472038 - Homographic and heterographic homophones in speech production: does orthography matter?
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-05
Journal Detail:
Title:  Cell     Volume:  150     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-23     Completed Date:  2012-10-01     Revised Date:  2012-10-16    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-88     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Institut National de la Santé et de la Recherche Médicale, U 855, Lyon 69372, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain / metabolism
Dietary Proteins / metabolism*
Intestines / metabolism
Mice, Knockout
Rats, Sprague-Dawley
Receptors, Opioid, mu / antagonists & inhibitors,  metabolism*
Satiety Response*
Reg. No./Substance:
0/Dietary Proteins; 0/Receptors, Opioid, mu
Comment In:
Nat Rev Neurosci. 2012 Sep;13(9):602
Cell Metab. 2012 Aug 8;16(2):137-9   [PMID:  22883226 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Safety and efficacy of ezogabine (retigabine) in adults with refractory partial-onset seizures: Inte...
Next Document:  MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors durin...