| Mr Outside and Mr Inside: classic and alternative views on the pathogenesis of rheumatoid arthritis. | |
| | |
MedLine Citation:
|
PMID: 20299352 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Different strategies can be applied to overcome an obstacle: one may either overcome it from the 'outside' or break it from the 'inside'. Similar strategies have been successfully used by two American football players in the 1940s, known as 'Mr Outside' and 'Mr Inside'. In this article, the authors propose similar concepts for initiating joint inflammation. Arthritis may start 'outside' as a primary inflammation of the synovial membrane (synovitis), which later spreads over to adjacent structures resulting in penetration into the bone marrow (outside-in concept). Alternatively, arthritis may start 'inside', in the bone marrow space, and later encroaches upon the synovium (inside-out concept). The authors discuss these two fundamentally different viewpoints on the pathogenesis of arthritis, each one of which bears attractive explanations for the mystery of the pathogenesis of arthritis. |
| | |
Authors:
|
Georg Schett; Gary S Firestein |
Publication Detail:
|
Type: Journal Article Date: 2010-03-18 |
Journal Detail:
|
Title: Annals of the rheumatic diseases Volume: 69 ISSN: 1468-2060 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-04-23 Completed Date: 2010-06-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
|
Languages: eng Pagination: 787-9 Citation Subset: IM |
Affiliation:
|
University of Erlangen, Erlangen D-91054, Germany. georg.schett@uk-erlangen.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Arthritis, Rheumatoid
/
etiology*,
pathology Humans Osteomyelitis / complications*, pathology Synovitis / complications*, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Exercise acutely reverses dysfunction of circulating angiogenic cells in chronic heart failure.
Next Document: IL-10/TGF-beta-modified macrophages induce regulatory T cells and protect against adriamycin nephros...