Document Detail

Moyamoya syndrome with intraventricular hemorrhage in an adult with factor V Leiden mutation.
MedLine Citation:
PMID:  16009774     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a case of proximal occlusion of 2 major cerebral vessels associated with moyamoya network circulation that manifested by spontaneous intraventricular hemorrhage. DESIGN: Case report. PATIENT AND RESULTS: A 36-year-old Syrian man presented with symptoms of sudden-onset headache, neck stiffness, and confusion. The computed tomography scan of his brain showed intraventricular bleeding, and the subsequent 4 vessel angiographies revealed occlusion of the left middle and anterior cerebral arteries with moyamoya appearance in the terminal branches. The coagulation profile showed the presence of heterozygous factor V Leiden mutation. The patient was treated conservatively until resolution of his blood clot, and later he was started on oral anticoagulation. CONCLUSION: Factor V Leiden mutation may cause large cerebral vessel occlusion with moyamoya syndrome in adults.
Rosette Jabbour; Ali Taher; Ali Shamseddine; Samir F Atweh
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  62     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-12     Completed Date:  2005-08-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1144-6     Citation Subset:  AIM; IM    
Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
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MeSH Terms
Anticoagulants / therapeutic use
Cerebral Angiography
Factor V / genetics*
Intracranial Hemorrhages / etiology*
Moyamoya Disease / complications*,  pathology*
Tomography, X-Ray Computed
Reg. No./Substance:
0/Anticoagulants; 0/factor V Leiden; 9001-24-5/Factor V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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