| Moyamoya disease in pediatric patients: outcomes of neurosurgical interventions. | |
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MedLine Citation:
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PMID: 18275292 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurosurgical interventions for moyamoya disease (MMD) in pediatric patients include direct, indirect, and combined revascularization procedures. Each technique has shown efficacy in the treatment of pediatric MMD; however, no single study has demonstrated the superiority of one technique over another. In this review, the authors explore the various studies focused on the use of these techniques for MMD in the pediatric population. They summarize the results of each study to clearly depict the clinical outcomes achieved at each institution that had utilized direct, indirect, or combined techniques. In certain studies, multiple techniques were used, and the clinical or radiological outcomes were compared accordingly. Direct techniques have been shown to aid a reduction in perioperative strokes and provide immediate revascularization to ischemic areas; however, these procedures are technically challenging, and not all pediatric patients are appropriate candidates. Indirect techniques have also shown efficacy in the pediatric population but may require a longer period for revascularization to occur and perfusion deficits to be reversed. The authors concluded that the clinical efficacy of one technique over another is still unclear, as most studies have had small populations and the same outcome measures have not been applied. Authors who compared direct and indirect techniques noted approximately equal clinical outcomes with differences in radiological findings. Additional, larger studies are needed to determine the advantages and disadvantages of the different techniques for the pediatric age group. |
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Authors:
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Anand Veeravagu; Raphael Guzman; Chirag G Patil; Lewis C Hou; Marco Lee; Gary K Steinberg |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Neurosurgical focus Volume: 24 ISSN: 1092-0684 ISO Abbreviation: Neurosurg Focus Publication Date: 2008 |
Date Detail:
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Created Date: 2008-02-15 Completed Date: 2008-04-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100896471 Medline TA: Neurosurg Focus Country: United States |
Other Details:
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Languages: eng Pagination: E16 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cerebral Revascularization
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methods* Child Humans Moyamoya Disease / surgery* Treatment Outcome |
| Comments/Corrections | |
Comment In:
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Neurosurg Focus. 2008;24(2):E16a; discussion E16a
[PMID:
18275293
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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