| Moxisylyte plasma kinetics in humans after intracavernous administration. | |
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MedLine Citation:
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PMID: 1467454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obtaining and sustaining an erection are common problems for the male spinal cord injury patient. Intracavernous injection of vasoactive substances offers a new treatment option but it must be approached with caution in this population. In this work, the use of an alpha-adrenergic blocking agent, moxisylyte, after intracavernous administration for complete paraplegic patients with erectile impotence is described. During this study, the pharmacokinetic profile of moxisylyte has been defined. Unchanged moxisylyte is not found in plasma, this drug is immediately metabolized after administration. Three metabolites were found in plasma: desacetylmoxisylyte (DAM), conjugated DAM, and conjugates of desmethylated DAM (MDAM). Maximum plasma levels of 72.3 ng ml-1, 301.4 ng ml-1, and 88.8 ng ml-1 are obtained 0.22 h, 0.9 h, and 2.08 h after drug administration for these three metabolites, respectively. The elimination half-lives are 0.89 h, 2.16 h, and 5.32 h and the MRT, 1.38 h, 3.23 h, and 8.45 h, respectively. No side-effects were noted, only one patient presented sleepiness. Successful erections (10 to 25 min) were obtained in all patients and no priapism was noted. |
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Authors:
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P Costa; F Bressolle; B Sarrazin; J Mosser; H Navratil; M Galtier |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biopharmaceutics & drug disposition Volume: 13 ISSN: 0142-2782 ISO Abbreviation: Biopharm Drug Dispos Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-01-25 Completed Date: 1993-01-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7911226 Medline TA: Biopharm Drug Dispos Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 671-9 Citation Subset: IM |
Affiliation:
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Service d'Urologie Andrologie, CHU Nîmes, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Hemodynamics / drug effects Humans Male Moxisylyte / metabolism, pharmacokinetics*, pharmacology Paraplegia / metabolism Penile Erection / drug effects |
| Chemical | |
Reg. No./Substance:
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54-32-0/Moxisylyte |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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