Document Detail


Moxisylyte plasma kinetics in humans after intracavernous administration.
MedLine Citation:
PMID:  1467454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obtaining and sustaining an erection are common problems for the male spinal cord injury patient. Intracavernous injection of vasoactive substances offers a new treatment option but it must be approached with caution in this population. In this work, the use of an alpha-adrenergic blocking agent, moxisylyte, after intracavernous administration for complete paraplegic patients with erectile impotence is described. During this study, the pharmacokinetic profile of moxisylyte has been defined. Unchanged moxisylyte is not found in plasma, this drug is immediately metabolized after administration. Three metabolites were found in plasma: desacetylmoxisylyte (DAM), conjugated DAM, and conjugates of desmethylated DAM (MDAM). Maximum plasma levels of 72.3 ng ml-1, 301.4 ng ml-1, and 88.8 ng ml-1 are obtained 0.22 h, 0.9 h, and 2.08 h after drug administration for these three metabolites, respectively. The elimination half-lives are 0.89 h, 2.16 h, and 5.32 h and the MRT, 1.38 h, 3.23 h, and 8.45 h, respectively. No side-effects were noted, only one patient presented sleepiness. Successful erections (10 to 25 min) were obtained in all patients and no priapism was noted.
Authors:
P Costa; F Bressolle; B Sarrazin; J Mosser; H Navratil; M Galtier
Related Documents :
24443514 - An international, multicentre survey of β-lactam antibiotic therapeutic drug monitorin...
23776774 - Cutaneous adverse drug reactions in a tertiary care teaching hospital: a north indian p...
3905334 - Importance of drug enantiomers in clinical pharmacology.
6723594 - Kinetics of penetration of common antiepileptic drugs into cerebrospinal fluid.
24304044 - Support vector machines for drug discovery.
2223424 - Actions of zopiclone and carbamazepine, alone and in combination, on human skilled perf...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biopharmaceutics & drug disposition     Volume:  13     ISSN:  0142-2782     ISO Abbreviation:  Biopharm Drug Dispos     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-01-25     Completed Date:  1993-01-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7911226     Medline TA:  Biopharm Drug Dispos     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  671-9     Citation Subset:  IM    
Affiliation:
Service d'Urologie Andrologie, CHU Nîmes, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Hemodynamics / drug effects
Humans
Male
Moxisylyte / metabolism,  pharmacokinetics*,  pharmacology
Paraplegia / metabolism
Penile Erection / drug effects
Chemical
Reg. No./Substance:
54-32-0/Moxisylyte

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical pharmacokinetics of procaterol: dose proportionality after administration of single oral do...
Next Document:  Sex-differences in the disposition of substituted benzamides: pharmacokinetics of a gastroprokinetic...