Document Detail

Moxisylyte plasma kinetics in humans after intracavernous administration.
MedLine Citation:
PMID:  1467454     Owner:  NLM     Status:  MEDLINE    
Obtaining and sustaining an erection are common problems for the male spinal cord injury patient. Intracavernous injection of vasoactive substances offers a new treatment option but it must be approached with caution in this population. In this work, the use of an alpha-adrenergic blocking agent, moxisylyte, after intracavernous administration for complete paraplegic patients with erectile impotence is described. During this study, the pharmacokinetic profile of moxisylyte has been defined. Unchanged moxisylyte is not found in plasma, this drug is immediately metabolized after administration. Three metabolites were found in plasma: desacetylmoxisylyte (DAM), conjugated DAM, and conjugates of desmethylated DAM (MDAM). Maximum plasma levels of 72.3 ng ml-1, 301.4 ng ml-1, and 88.8 ng ml-1 are obtained 0.22 h, 0.9 h, and 2.08 h after drug administration for these three metabolites, respectively. The elimination half-lives are 0.89 h, 2.16 h, and 5.32 h and the MRT, 1.38 h, 3.23 h, and 8.45 h, respectively. No side-effects were noted, only one patient presented sleepiness. Successful erections (10 to 25 min) were obtained in all patients and no priapism was noted.
P Costa; F Bressolle; B Sarrazin; J Mosser; H Navratil; M Galtier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biopharmaceutics & drug disposition     Volume:  13     ISSN:  0142-2782     ISO Abbreviation:  Biopharm Drug Dispos     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-01-25     Completed Date:  1993-01-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7911226     Medline TA:  Biopharm Drug Dispos     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  671-9     Citation Subset:  IM    
Service d'Urologie Andrologie, CHU Nîmes, France.
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MeSH Terms
Hemodynamics / drug effects
Moxisylyte / metabolism,  pharmacokinetics*,  pharmacology
Paraplegia / metabolism
Penile Erection / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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