| Movement reduces the dynamic response of muscle spindle afferents and motoneuron synaptic potentials in rat. | |
| | |
MedLine Citation:
|
PMID: 14695354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Among the mechanisms that may result in modulation of the stretch reflex by the recent history of muscle contraction is the history dependence observed under some conditions in the response properties of muscle spindles. The present study was designed to test one report that in successive trials of muscle stretch-release, spindle afferent firing during stretch, i.e., the dynamic response shows no history dependence beyond the initial burst of firing at stretch onset. Firing responses of spindle afferents were recorded during sets of three consecutive trials of triangular stretch-release applied to triceps surae muscles in barbiturate-anesthetized rats. All 69 spindle afferents fired more action potentials (spikes) during the dynamic response of the first trial, excluding the initial burst, than in the following two trials. The reduced dynamic response (RDR) was nearly complete after trial 1 and amounted to an average of approximately 12 fewer spikes (16 pps slower firing rate) in trial 3 than in trial 1. RDR was sensitive to the interval between stretch sets but independent of stretch velocity (4-32 mm/s). RDR was reflected in the synaptic potentials recorded intracellularly from 16 triceps surae alpha-motoneurons: depolarization during muscle stretch was appreciably reduced after trial 1. These findings demonstrate history dependence of spindle afferent responses that extends throughout the dynamic response in successive muscle stretches and that is synaptically transmitted to motoneurons with the probable effect, unless otherwise compensated, of modulating the stretch reflex. |
| | |
Authors:
|
Valerie K Haftel; Edyta K Bichler; T Richard Nichols; Martin J Pinter; Timothy C Cope |
Related Documents
:
|
7121054 - A mechanographic method for measurement of muscle tone in the conscious rat. the calf m... 18456884 - The landing-take-off asymmetry of human running is enhanced in old age. 23188744 - Systems analysis of biological networks in skeletal muscle function. 4271734 - Evidence from the use of vibration during procaine nerve block that the spindle group i... 3222624 - A test for muscle lesions and their regeneration following intramuscular drug application. 9016454 - Comparison of skeletal muscle microcirculation between clamp ischemia and microsurgical... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2003-12-24 |
Journal Detail:
|
Title: Journal of neurophysiology Volume: 91 ISSN: 0022-3077 ISO Abbreviation: J. Neurophysiol. Publication Date: 2004 May |
Date Detail:
|
Created Date: 2004-04-07 Completed Date: 2004-05-25 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0375404 Medline TA: J Neurophysiol Country: United States |
Other Details:
|
Languages: eng Pagination: 2164-71 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Emory University, Atlanta, Georgia 30322, USA. vhaftel@morehouse.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Axons / physiology Electrodes, Implanted Evoked Potentials, Motor / physiology* Female Motor Neurons / physiology* Movement / physiology* Muscle Spindles / physiology* Muscle, Skeletal / innervation*, physiology* Neurons, Afferent / physiology* Rats Rats, Wistar Reflex, Stretch / physiology Synapses / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
P01 NS-40405/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evidence that phospholipase D activation prevents group I mGluR-induced persistent prolongation of e...
Next Document: Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic ...