| Movement, imaging and neurobehavioral assessment as predictors of cerebral palsy in preterm infants. | |
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MedLine Citation:
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PMID: 17304207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the relative efficacy of three early predictors of cerebral palsy. METHOD: One Hundred and thirty infants with birth weight <1500 g were recruited. Video recordings of spontaneous general movements were made at 36 and 52 weeks postconceptional age. Magnetic resonance imaging and the neurobehavioral assessment of the preterm infant were done at 36 weeks postconceptional age. Follow-up neurological examination and Bayley assessments were made at 18 months corrected age to make early identification of cerebral palsy. RESULTS: Magnetic resonance imaging gave the best specificity and accuracy of 91 and 84% respectively. General movements at 52 weeks showed an improved specificity and accuracy over performance at 36 weeks postconceptional age. The negative predictive value for all methods tested was between 90 and 97%. Combining the results of magnetic resonance imaging and the neurobehavioral assessment improved the sensitivity of prediction to 80%, suggesting that a holistic approach to early detection of cerebral lesions is preferable to a single test. CONCLUSIONS: The majority of infants who appeared to behave within normal limits and exhibit normal brain structure in the newborn period were classified as neurologically intact at follow-up. |
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Authors:
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J C Constantinou; E N Adamson-Macedo; M Mirmiran; B E Fleisher |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-02-15 |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 27 ISSN: 0743-8346 ISO Abbreviation: J Perinatol Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-22 Completed Date: 2007-05-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 225-9 Citation Subset: IM |
Affiliation:
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Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Janet.constantinou@stanford.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cerebral Palsy
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diagnosis* Early Diagnosis Female Humans Infant Infant, Newborn Infant, Premature / growth & development*, physiology Magnetic Resonance Imaging Male Movement* Predictive Value of Tests Respiration, Artificial / adverse effects* Sensitivity and Specificity Video Recording |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR000070/RR/NCRR NIH HHS |
| Comments/Corrections | |
Comment In:
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J Perinatol. 2007 May;27(5):259-61
[PMID:
17453038
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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