Document Detail


Movement disorder in Down's syndrome: a possible marker of the severity of mental handicap.
MedLine Citation:
PMID:  8813219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the nature and prevalence of abnormal movements in adults with Down's syndrome and also the clinical correlates of orofacial dyskinesia and the relationship between dyskinesia and the level of functional and intellectual disability. Movement disorder, language age, and disability were assessed in an epidemiologically based sample of 145 individuals with Down's syndrome. Abnormal involuntary movements were common, with > 90% exhibiting dyskinesia, predominantly orofacial. Stereotypes were present in one-third of the sample. There was an association between the severity of dyskinesia and both current language age and functioning in terms of self-care and practical and academic skills, which suggested that dyskinesia may be a marker of the severity of mental handicap. The presence of dyskinesia was unrelated to neuroleptic exposure. Dyskinesia and stereotypies are very common in individuals with Down's syndrome and may represent an inherent manifestation of the disorder. The relationship between mental age and dyskinesia in Down's syndrome warrants further research.
Authors:
C M Haw; T R Barnes; K Clark; P Crichton; D Kohen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  11     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-26     Completed Date:  1996-12-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  395-403     Citation Subset:  IM    
Affiliation:
Fair Mile Hospital, Cholsey, Oxon, U.K.
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MeSH Terms
Descriptor/Qualifier:
Activities of Daily Living / classification
Adult
Disability Evaluation
Down Syndrome / diagnosis,  genetics*
Female
Genetic Markers / genetics
Humans
Intelligence / genetics
Language Development Disorders / diagnosis,  genetics
Male
Middle Aged
Movement Disorders / diagnosis,  genetics*
Neurologic Examination
Risk Factors
Stereotyped Behavior / physiology
Chemical
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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