Document Detail


Movement-activated myoclonus in genetically defined progressive myoclonic epilepsies: EEG-EMG relationship estimated using autoregressive models.
MedLine Citation:
PMID:  12804673     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study electroencephalography-electromyography (EEG-EMG) relationships in patients with different forms of progressive myoclonic epilepsies (PME). METHODS: EEG-EMG auto-spectra, coherence and phase functions were estimated by means of bivariate and time varying autoregressive (AR) models in 15 patients: 8 with Unverricht-Lundborg, 4 with Lafora body disease, and 3 with sialidosis. RESULTS: The coherence spectra of the EMG epochs including action myoclonus and contralateral frontocentral EEG derivations showed a main beta peak (average coherence: 0.60-0.79) in all patients, regardless of the type of PME. The time lag from cortex to muscle was 13.0-21.3 ms. Significantly, coherent gamma activity was consistently found only in the 3 patients with sialidosis; the most heterogeneous results were obtained in the patients with Lafora disease, who showed a more complex coherence profile. Periods of normal muscle contractions, which could be recorded in patients with Unverricht-Lundborg PME, were characterised by the presence of an EEG-EMG beta coherence peak on the same frequency as in the case of action myoclonus, but with a lower coherence value. CONCLUSIONS: AR models were capable of describing EEG-EMG relationships in patients with PME, and indicated that coherent cortical and EMG beta oscillations are crucially involved in the generation of myoclonus. Moreover, they could detect the uneven spectral profiles characterising the different forms of PME.
Authors:
F Panzica; L Canafoglia; S Franceschetti; S Binelli; C Ciano; E Visani; G Avanzini
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  114     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-13     Completed Date:  2003-08-01     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1041-52     Citation Subset:  IM    
Affiliation:
National Neurological Institute C. Besta, Via Celoria 11, 20133, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Electroencephalography*
Electromyography*
Female
Functional Laterality
Humans
Male
Middle Aged
Mucolipidoses / complications,  physiopathology
Myoclonic Epilepsies, Progressive / classification,  genetics,  physiopathology*
Myoclonus / diagnosis,  etiology*
Regression Analysis*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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