Document Detail


Movement outcomes of infants born moderate and late preterm.
MedLine Citation:
PMID:  23772915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate whether children born between 32 and 36 weeks of gestation have an increased risk of motor coordination difficulties or cerebral palsy (CP) at age 7 years.
METHODS: A cohort study based on the Avon Longitudinal Study of Parents and Children (ALSPAC). The primary outcomes were poor motor coordination, defined as an ALSPAC coordination test score <5th centile or the presence of CP. Exposure groups were defined as moderate or late preterm (32-36 weeks of gestation) or term (37-42 weeks). Regression models were used to investigate the association between gestational age and outcomes. Multiple imputation was used to account for missing covariate data.
RESULTS: In the fully adjusted model, there was strong evidence that children born at moderate or late preterm had worse coordination (OR 1.41 (1.14-1.74)) and higher risk of CP (OR 6.38 (2.28-17.76)) than term peers. However, restricting the analysis to well-grown infants born vaginally, in good condition, the associations attenuated substantially.
CONCLUSIONS: Moderate or late preterm infants were at increased risk of developing coordination problems and cerebral palsy. After restricting the analysis to 'well' infants the associations of gestation with the coordination measures and CP reduced substantially, suggesting that antenatal, intrapartum and neonatal causal pathways are likely to be involved.
Authors:
David Edward Odd; Raghu Lingam; Alan Emond; Andrew Whitelaw
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-07-12
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  102     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-05     Completed Date:  2013-10-31     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  876-82     Citation Subset:  IM    
Copyright Information:
©2013 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
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MeSH Terms
Descriptor/Qualifier:
Age Distribution
Analysis of Variance
Cerebral Palsy / diagnosis*,  epidemiology*
Child
Child, Preschool
Cohort Studies
Confidence Intervals
Female
Gestational Age*
Humans
Incidence
Infant
Infant, Newborn
Infant, Premature*
Longitudinal Studies
Male
Motor Skills Disorders / diagnosis,  epidemiology*
Odds Ratio
Prognosis
Risk Assessment
Severity of Illness Index
Sex Distribution
Grant Support
ID/Acronym/Agency:
076467//Wellcome Trust; 74882//Medical Research Council; G9815508//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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