Document Detail


Mouse oviduct development.
MedLine Citation:
PMID:  22918811     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The oviduct, or Fallopian tube in humans, transports oocytes and sperm, serves as the site of fertilization, and supports early embryonic development. The oviduct is essential for fertility. In the mouse, the oviduct is a coiled, complex structure that develops from the simple embryonic Müllerian duct. The oviduct consists of four segments, including the infundibulum, ampulla, isthmus, and uterotubal junction. Additionally, the mouse oviduct forms coils, develops longitudinal folds, and undergoes both mesenchymal and epithelial differentiation. Oviduct development and differentiation occurs perinatally. Several signaling pathways have been found to be involved in oviduct formation, such as Wnt, Tgfβ, microRNA processing, as well as others. Overall, the process of oviduct development is poorly understood and can be utilized to further knowledge of epithelial-mesenchymal interactions, regulation of coiling, characteristics of pseudostratified epithelia, and smooth muscle differentiation.
Authors:
C Allison Stewart; Richard R Behringer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Results and problems in cell differentiation     Volume:  55     ISSN:  0080-1844     ISO Abbreviation:  Results Probl Cell Differ     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173555     Medline TA:  Results Probl Cell Differ     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  247-62     Citation Subset:  IM    
Affiliation:
Department of Genetics, University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA.
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