Document Detail


Mouse oocyte control of granulosa cell development and function: paracrine regulation of cumulus cell metabolism.
MedLine Citation:
PMID:  19197803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bidirectional communication between oocytes and the companion granulosa cells is essential for the development and functions of both compartments. Oocytes are deficient in their ability to transport certain amino acids and in carrying out glycolysis and cholesterol biosynthesis. Cumulus cells must provide them with the specific amino acids and the products in these metabolic pathways. Oocytes control metabolic activities in cumulus cells by promoting the expression of genes in cumulus cells encoding specific amino acid transporters and enzymes essential for the oocyte-deficient metabolic processes. Hence oocytes outsource metabolic functions to cumulus cells to compensate for oocyte metabolic deficiencies. Oocyte control of granulosa cell metabolism may also participate in regulating the rate of follicular development in coordination with endocrine, paracrine, and autocrine signals. Oocytes influence granulosa cell development mainly by secretion of paracrine factors, although juxtacrine signals probably also participate. Key oocyte-derived paracrine factors include growth differentiation factor 9, bone morphogenetic protein 15, and fibroblast growth factor 8B.
Authors:
You-Qiang Su; Koji Sugiura; John J Eppig
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-02-05
Journal Detail:
Title:  Seminars in reproductive medicine     Volume:  27     ISSN:  1526-4564     ISO Abbreviation:  Semin. Reprod. Med.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-06     Completed Date:  2009-04-02     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  100909394     Medline TA:  Semin Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-42     Citation Subset:  IM    
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609, USA. youqiang.su@jax.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / physiology
Cumulus Cells / metabolism*
Female
Granulosa Cells / metabolism,  physiology*
Mice
Models, Biological
Oocytes / physiology*
Paracrine Communication / physiology*
Grant Support
ID/Acronym/Agency:
HD 44416/HD/NICHD NIH HHS; HD21970/HD/NICHD NIH HHS; HD23839/HD/NICHD NIH HHS; R01 HD023839-19/HD/NICHD NIH HHS; R37 HD021970-24/HD/NICHD NIH HHS; U01 HD044416-05/HD/NICHD NIH HHS
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