Document Detail


Mouse myotomes pairs exhibit left-right asymmetric expression of MLC3F and alpha-skeletal actin.
MedLine Citation:
PMID:  15499557     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Most muscle originates from the myotomal compartment of the somites, paired structures flanking the neural tube. Whereas vertebrate embryos show molecular and morphological asymmetry about the left-right body axis, somitic myogenesis is thought to occur symmetrically. Here, we provide the first evidence that myotome pairs are transiently left-right asymmetric, with higher expression of alpha-skeletal actin and myosin light chain 3F (MLC3F) on the left side between embryonic day 9.5-10.25. In iv mutants with situs inversus, the asymmetric expression of alpha-skeletal actin and MLC3F was inverted, showing that this process is regulated by global left-right axis cues, initiated before gastrulation. However, although left-sided identity is later maintained by Pitx2 genes, we found that Pitx2c null embryos have normal left-biased expression of alpha-skeletal actin and MLC3F. Myotome asymmetry, therefore, is downstream of the iv mutation but upstream of, or unrelated to, the Pitx2c pathway.
Authors:
Jon P Golding; Terence A Partridge; Jonathan R Beauchamp; Tim King; Nigel A Brown; Martin Gassmann; Peter S Zammit
Related Documents :
3597997 - Bundle branch block in patients with chronic coronary artery disease: angiographic corr...
14639027 - Unusual growth of a left atrial myxoma complicated by a secundum atrial septal defect.
1286477 - Right atrial myxoma presenting with recurrent episodes of pulmonary embolism.
1248077 - Electrophysiological and clinical observations in patients with alternating bundle bran...
21254247 - The neurovascular relationships of the oculomotor nerve.
9149607 - Aortic root abscess with fistula formation.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  231     ISSN:  1058-8388     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-23     Completed Date:  2005-04-18     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  795-800     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2004 Wiley-Liss, Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Actins / genetics*
Animals
Embryonic Development / physiology*
Female
Gene Expression Regulation, Developmental
Homeodomain Proteins / genetics
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Muscle, Skeletal / embryology*,  physiology
Myosin Light Chains / genetics*
Nuclear Proteins / genetics
Pregnancy
Situs Inversus / genetics,  physiopathology*
Transcription Factors
Grant Support
ID/Acronym/Agency:
G113/31//Medical Research Council
Chemical
Reg. No./Substance:
0/Actins; 0/Homeodomain Proteins; 0/Myosin Light Chains; 0/Nuclear Proteins; 0/Transcription Factors; 184787-43-7/homeobox protein PITX2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Myogenic regulatory factors: redundant or specific functions? Lessons from Xenopus.
Next Document:  Synthesis of spiro[5.4]decenones and their transformation into bicyclo[4.4]deca-1,4-dien-3-ones by d...