Document Detail


Mouse models of growth hormone action and aging: a proteomic perspective.
MedLine Citation:
PMID:  23019135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Growth hormone (GH) is a protein secreted by the anterior pituitary and circulates throughout the body to exert important actions on growth and metabolism. GH stimulates the secretion of insulin-like growth factor-I (IGF-I) that mediates some of the growth promoting actions of GH. The GH/IGF-I axis has recently been recognized as important in terms of longevity in organisms ranging from Caenorhabditis elegans to mice. For example, GH transgenic mice possess short lifespans while GH receptor null (GHR-/-) mice have extended longevity. Thus, the actions of GH (or IGF-I) or lack thereof impact the aging process. In this review, we summarize the proteomic analyses of plasma and white adipose tissue in these two mouse models of GH action, i.e. GH transgenic and GHR-/- mice. At the protein level, we wanted to establish novel plasma biomarkers of GH action as a function of age and to determine differences in adipose tissue depots. We have shown that these proteomic approaches have not only confirmed several known physiological actions of GH, but also resulted in novel protein biomarkers and targets that may be indicative of the aging process and/or new functions of GH. These results may generate new directions for GH and/or aging research.
Authors:
Juan Ding; Lucila Sackmann-Sala; John J Kopchick
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-11-26
Journal Detail:
Title:  Proteomics     Volume:  13     ISSN:  1615-9861     ISO Abbreviation:  Proteomics     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-18     Completed Date:  2013-07-31     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  101092707     Medline TA:  Proteomics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  674-85     Citation Subset:  IM    
Copyright Information:
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue, White / metabolism
Aging / metabolism*
Animals
Blood Proteins / metabolism
Gene Knockout Techniques
Growth Hormone / physiology*
Humans
Insulin / physiology
Insulin Resistance
Insulin-Like Growth Factor I / physiology
Lipid Metabolism
Proteome / metabolism*
Proteomics
Receptors, Somatotropin / deficiency,  genetics
Grant Support
ID/Acronym/Agency:
AG019899/AG/NIA NIH HHS; DK075436/DK/NIDDK NIH HHS; P01 AG031736/AG/NIA NIH HHS; P01AG031736/AG/NIA NIH HHS; R15 DK075436/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Insulin; 0/Proteome; 0/Receptors, Somatotropin; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone
Comments/Corrections

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