| Mouse models for extracellular matrix diseases. | |
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MedLine Citation:
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PMID: 9535558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mutations of a number of genes encoding for extracellular matrix (ECM) proteins in mice have provided new insights regarding their role during development and disease. Many mouse strains have helped to verify the link between mutation and disease in humans, and others have produced unexpected phenotypes and identified new functions for ECM proteins. Finally, some null mutations in ECM genes provide no phenotypic alterations in mice, confronting the scientific community with a new challenge to search for their functions. This review lists all mouse strains with spontaneous and experimentally induced mutations in ECM genes. The phenotypes of these mice are discussed in comparison with the human diseases. |
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Authors:
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A Aszódi; A Pfeifer; M Wendel; L Hiripi; R Fässler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of molecular medicine (Berlin, Germany) Volume: 76 ISSN: 0946-2716 ISO Abbreviation: J. Mol. Med. Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-05-18 Completed Date: 1998-05-18 Revised Date: 2011-07-08 |
Medline Journal Info:
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Nlm Unique ID: 9504370 Medline TA: J Mol Med (Berl) Country: GERMANY |
Other Details:
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Languages: eng Pagination: 238-52 Citation Subset: IM |
Affiliation:
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Max-Planck Institut für Biochemie, Martinsried, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Connective Tissue Diseases* Disease Models, Animal Extracellular Matrix / genetics* Humans Mice Mice, Mutant Strains* Mice, Transgenic* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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