Document Detail

Mouse models of apnea: strain differences in apnea expression and its pharmacologic and genetic modification.
MedLine Citation:
PMID:  20217371     Owner:  NLM     Status:  MEDLINE    
Mouse strain differences exist in post-hypoxic ventilatory behavior, specifically, the C57BL/6 J (B6) mouse exhibits irregular breathing including apnea during re-oxygenation after acute hypoxic exposure, while A/J mouse does not. This phenomenon of the B6 mouse responding to the hypoxia-reoxygenation cycle which is a mimic of human sleep apnea syndrome let us consider the B6 mouse as an animal model of sleep apnea. Moreover, the B6 mouse tends to show spontaneous apnea and post-sigh apnea compared to the A/J mouse. In this brief review, we present evidence that pharmacologic approaches as well as genetic modification can improve irregular breathing including apnea in the B6, suggesting that these pharmacologic treatment might be effective for the patients with sleep apnea who cannot tolerate nCPAP. Moreover our findings regarding genetic difference and modification should be helpful to explore the pathogenesis of sleep apnea.
Motoo Yamauchi; Hiroshi Kimura; Kingman P Strohl
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  669     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  303-7     Citation Subset:  IM    
Department of Respiratory Medicine, Nara Medical University, Nara, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acetazolamide / pharmacology,  therapeutic use
Buspirone / pharmacology,  therapeutic use
Disease Models, Animal*
Pulmonary Ventilation / drug effects
Respiratory Mechanics / drug effects
Respiratory System / drug effects,  physiopathology
Sleep Apnea Syndromes / drug therapy*,  genetics*,  physiopathology
Species Specificity
Grant Support
Reg. No./Substance:
36505-84-7/Buspirone; 59-66-5/Acetazolamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Repeated Obstructive Apneas Induce Long-term Facilitation of Genioglossus Muscle Tone.
Next Document:  Influence of cycling history on the ventilatory response to cycle-ergometry in humans: a role for re...