Document Detail


Mouse models of apnea: strain differences in apnea expression and its pharmacologic and genetic modification.
MedLine Citation:
PMID:  20217371     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mouse strain differences exist in post-hypoxic ventilatory behavior, specifically, the C57BL/6 J (B6) mouse exhibits irregular breathing including apnea during re-oxygenation after acute hypoxic exposure, while A/J mouse does not. This phenomenon of the B6 mouse responding to the hypoxia-reoxygenation cycle which is a mimic of human sleep apnea syndrome let us consider the B6 mouse as an animal model of sleep apnea. Moreover, the B6 mouse tends to show spontaneous apnea and post-sigh apnea compared to the A/J mouse. In this brief review, we present evidence that pharmacologic approaches as well as genetic modification can improve irregular breathing including apnea in the B6, suggesting that these pharmacologic treatment might be effective for the patients with sleep apnea who cannot tolerate nCPAP. Moreover our findings regarding genetic difference and modification should be helpful to explore the pathogenesis of sleep apnea.
Authors:
Motoo Yamauchi; Hiroshi Kimura; Kingman P Strohl
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  669     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  303-7     Citation Subset:  IM    
Affiliation:
Department of Respiratory Medicine, Nara Medical University, Nara, Japan. motoo@naramed-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Acetazolamide / pharmacology,  therapeutic use
Animals
Buspirone / pharmacology,  therapeutic use
Disease Models, Animal*
Humans
Mice
Pulmonary Ventilation / drug effects
Recurrence
Respiratory Mechanics / drug effects
Respiratory System / drug effects,  physiopathology
Sleep Apnea Syndromes / drug therapy*,  genetics*,  physiopathology
Species Specificity
Grant Support
ID/Acronym/Agency:
NS052452/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
36505-84-7/Buspirone; 59-66-5/Acetazolamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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