| Mouse model of fragile X syndrome: behavioral and hormonal response to stressors. | |
| | |
MedLine Citation:
|
PMID: 19485574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fragile X syndrome, a form of mental retardation caused by inadequate levels of fragile X mental retardation protein (FMRP), is characterized by extreme sensitivity to sensory stimuli and increased behavioral and hormonal reactivity to stressors. Fmr1 knockout mice lack FMRP and exhibit abnormal responses to auditory stimuli. This study sought to determine whether Fmr1 knockout mice on an F1 hybrid background are normal in their response to footshock. Knockout mice were also examined for signs of hyperexcitation across an extended trial range, and serum corticosterone levels were evaluated in response to various stressors. The ability to acquire conditioned taste aversion was also assessed. Knockout mice exhibited no impairment in associative aversive learning or memory, since they successfully expressed conditioned taste aversion. Footshock-sensitivity, freezing behavior, and corticosterone response to various stressors did not differ between knockout and wild-type mice. However, knockout mice exhibited significantly increased responses during the extended test. The knockout mice's increased responsiveness to footshock in the extended test may be an indication of increased vulnerability to stress or enhanced emotional reactivity. |
| | |
Authors:
|
Darci M Nielsen; Jeffrey J Evans; William J Derber; Kenzie A Johnston; Mark L Laudenslager; Linda S Crnic; Kenneth N Maclean |
Related Documents
:
|
16011574 - Behavioral and neurochemical phenotyping of homer1 mutant mice: possible relevance to s... 15238994 - Expression of the cs- and us-pre-exposure effects in the conditioned taste aversion par... 986664 - Resistance of androgen-mediated aggressive behavior in mice to flutamide, an antiandrogen. 17097724 - Typical and atypical antipsychotic drug effects on locomotor hyperactivity and deficits... 9782314 - Coronavirus mhv-a59 causes upregulation of interferon-beta rna in primary glial cell cu... 18327484 - The effect of antioxidant properties of aqueous garlic extract and nigella sativa as an... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Behavioral neuroscience Volume: 123 ISSN: 0735-7044 ISO Abbreviation: Behav. Neurosci. Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-06-02 Completed Date: 2009-08-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8302411 Medline TA: Behav Neurosci Country: United States |
Other Details:
|
Languages: eng Pagination: 677-86 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2009 APA, all rights reserved. |
Affiliation:
|
Department of Pediatrics, University of Colorado Denver Medical School, Aurora, CO 80045, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Association Learning / physiology Avoidance Learning / physiology Conditioning (Psychology) / physiology Corticosterone / blood Disease Models, Animal Electroshock Fragile X Mental Retardation Protein / genetics Fragile X Syndrome / physiopathology*, psychology* Freezing Reaction, Cataleptic Male Memory / physiology Mice Mice, Inbred C57BL Mice, Knockout Restraint, Physical Stress, Psychological / physiopathology* Swimming Taste |
| Grant Support | |
ID/Acronym/Agency:
|
HD017449/HD/NICHD NIH HHS; HD04024/HD/NICHD NIH HHS; HD047029/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fmr1 protein, mouse; 139135-51-6/Fragile X Mental Retardation Protein; 50-22-6/Corticosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Delay eyeblink classical conditioning is impaired in Fragile X syndrome.
Next Document: How fast are feedforward postural adjustments of the abdominal muscles?