Document Detail

Mouse lung immune response after acute exposure to flour dust.
MedLine Citation:
PMID:  9210732     Owner:  NLM     Status:  MEDLINE    
To approach the physiopathology of the mucosal immune response in flour-mill and bakery workers, the authors developed a mouse model, which allowed them to study immune responses induced in the deep lung by acute inhalation of flour dust. In situ quantification of T lymphocytes (Thy1-2) and T-cell subsets (CD4 and CD8), macrophages, B lymphocytes, and immunoglobulin A plasma cells in the lungs of all animals revealed significant modifications of these cell compartments as early as 3 d after exposure; within 10 d of exposure, levels returned to baseline. The data suggest that the lung could be a sensitive target for inhaled xenobiotics, which might generate rapid immune local modifications that result in the maintenance of homeostasis.
M N Kolopp-Sarda; M C Béné; P Martin; G C Faure
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of environmental health     Volume:  52     ISSN:  0003-9896     ISO Abbreviation:  Arch. Environ. Health     Publication Date:    1997 Jul-Aug
Date Detail:
Created Date:  1997-07-23     Completed Date:  1997-07-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0212627     Medline TA:  Arch Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  304-8     Citation Subset:  AIM; IM    
Laboratoire d'Immunologie, Faculté de Médecine de Nancy, Vandoeuvre-lès-Nancy, France.
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MeSH Terms
Administration, Inhalation
Dust / adverse effects*
Flour / adverse effects*
Fluorescent Antibody Technique / statistics & numerical data
Immunity, Cellular / drug effects
Lung / drug effects,  immunology*
Macrophages, Alveolar / drug effects,  enzymology
Time Factors
Reg. No./Substance:

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