Document Detail

Mouse lethal activity of a HEp-2 vacuolation factor, cereulide, produced by Bacillus cereus isolated from vomiting-type food poisoning.
MedLine Citation:
PMID:  8916007     Owner:  NLM     Status:  MEDLINE    
The HEp-2 vacuolation factor (or cereulide) produced by Bacillus cereus isolated from vomiting-type food poisoning, which is supposed to induce emesis, was found to give mouse and suncus lethality after intravenous and intraperitoneal administration. The emetic activity of the factor was also found to be resistant to heating at 121 degrees C for 15 min, exposure to pH 2 and 11, and to digestion with proteolytic enzymes such as pepsin and trypsin. These findings suggest that the cereulide produced by B. cereus is stable in the digestive tracts, induce emesis, and show lethal activity leading to cellular damage.
K Shinagawa; Y Ueno; D Hu; S Ueda; S Sugii
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  58     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-07-08     Completed Date:  1997-07-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1027-9     Citation Subset:  IM    
Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University, Japan.
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MeSH Terms
Bacillus cereus / metabolism*
Bacterial Toxins / isolation & purification,  toxicity*
Dose-Response Relationship, Drug
Foodborne Diseases / microbiology*
Injections, Intraperitoneal
Injections, Intravenous
Mice, Inbred ICR
Peptides, Cyclic / isolation & purification,  toxicity*
Vomiting / microbiology
Reg. No./Substance:
0/Bacterial Toxins; 0/Depsipeptides; 0/Peptides, Cyclic; 0/cereulide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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