| Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. | |
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MedLine Citation:
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PMID: 17481602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an effort to identify Otx2 targets in mouse anterior neuroectoderm we identified a gene, mShisa, which is homologous to xShisa1 that we previously reported as a head inducer in Xenopus. mShisa encodes an antagonist against both Wnt and Fgf signalings; it inhibits these signalings cell-autonomously as xShisa1 does. The mShisa expression is lost or greatly reduced in Otx2 mutant visceral endoderm, anterior mesendoderm and anterior neuroectoderm. However, mShisa mutants exhibited no defects in head development. Shisa is composed of five subfamilies, but normal head development in mShisa mutants is unlikely to be explained in terms of the compensation of mShisa deficiency by its paralogues or by known Wnt antagonists in anterior visceral endoderm and/or anterior mesendoderm. |
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Authors:
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Kenryo Furushima; Akihito Yamamoto; Takashi Nagano; Mikihito Shibata; Hitoshi Miyachi; Takaya Abe; Naoko Ohshima; Hiroshi Kiyonari; Shinichi Aizawa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-27 |
Journal Detail:
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Title: Developmental biology Volume: 306 ISSN: 0012-1606 ISO Abbreviation: Dev. Biol. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-11 Completed Date: 2007-08-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: United States |
Other Details:
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Languages: eng Pagination: 480-92 Citation Subset: IM |
Affiliation:
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Laboratory for Animal Resources and Genetic Engineering, Center for Developmental Biology (CDB), RIKEN Kobe, 2-2-3 Minatojima Minami, Chuo-ku, Kobe 650-0047, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Base Sequence Endoderm / metabolism Fibroblast Growth Factors / antagonists & inhibitors, genetics* Gene Expression Regulation* Gene Expression Regulation, Developmental* Humans Membrane Proteins / genetics*, physiology* Mesoderm / metabolism Mice Mice, Transgenic Molecular Sequence Data Wnt Proteins / antagonists & inhibitors, genetics* Xenopus |
| Chemical | |
Reg. No./Substance:
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0/Membrane Proteins; 0/Shisa protein, mouse; 0/Wnt Proteins; 62031-54-3/Fibroblast Growth Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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