Document Detail


Mouse germ cell development during embryogenesis.
MedLine Citation:
PMID:  18625315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The discrimination and differentiation of germ cells from somatic cells is a fundamental issue during development. The early specification of mouse primordial germ cells (PGCs) is achieved by the induction of Blimp1, a key regulator of germ cells. Nanos3 is one of the genes activated in early PGCs and prevents apoptosis during their migration stage. Once PGCs enter the embryonic gonads, they differentiate according to the somatic sex of the organism. During this process, Nanos2 plays an important role as it promotes male germ cell pathway by suppressing the female fate. In this review, the process of germ cell development in the mouse is discussed with a particular focus on the functions of the key proteins, Blimp1, Nanos, and Dead end1.
Authors:
Yumiko Saga
Related Documents :
2995655 - Cyclic nucleotide phosphodiesterases in somatic and germ cells of mouse seminiferous tu...
19285665 - Testis atrophy and reduced sperm motility in transgenic mice overexpressing c-flip(l).
11191075 - Lack of significant morphological differences between human x and y spermatozoa and the...
19279705 - De novo morphogenesis of functional testis tissue after ectopic transplantation of isol...
23805245 - The effect of z-ligustilide on the mobility of human glioblastoma t98g cells.
25124605 - Mirna-1297 induces cell proliferation by targeting phosphatase and tensin homolog in te...
Publication Detail:
Type:  Journal Article; Review     Date:  2008-07-28
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  18     ISSN:  0959-437X     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-10-22     Completed Date:  2009-01-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  England    
Other Details:
Languages:  eng     Pagination:  337-41     Citation Subset:  IM    
Affiliation:
Division of Mammalian Development, National Institute of Genetics, Graduate University for Advanced Studies (SOKENDAI), Yata 1111, Mishima, Shizuoka 411-8540, Japan. ysaga@lab.nig.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning / physiology
Carrier Proteins / genetics,  physiology
Cell Movement / physiology
Embryonic Development / genetics,  physiology*
Female
Germ Cells / growth & development*
Male
Mice
Models, Biological
Neoplasm Proteins / genetics,  physiology
Proto-Oncogene Proteins c-kit / genetics,  physiology
RNA-Binding Proteins / genetics,  physiology
Sex Differentiation / genetics,  physiology
Signal Transduction / genetics
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Dnd1 protein, mouse; 0/Nanos2 protein, mouse; 0/Nanos3 protein, mouse; 0/Neoplasm Proteins; 0/RNA-Binding Proteins; EC 2.7.10.1/Proto-Oncogene Proteins c-kit

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Skeletal muscle stem cells.
Next Document:  Synthesis and biological effect of halogen substituted phenyl acetic acid derivatives of progesteron...