Document Detail

Mouse germ cell development during embryogenesis.
MedLine Citation:
PMID:  18625315     Owner:  NLM     Status:  MEDLINE    
The discrimination and differentiation of germ cells from somatic cells is a fundamental issue during development. The early specification of mouse primordial germ cells (PGCs) is achieved by the induction of Blimp1, a key regulator of germ cells. Nanos3 is one of the genes activated in early PGCs and prevents apoptosis during their migration stage. Once PGCs enter the embryonic gonads, they differentiate according to the somatic sex of the organism. During this process, Nanos2 plays an important role as it promotes male germ cell pathway by suppressing the female fate. In this review, the process of germ cell development in the mouse is discussed with a particular focus on the functions of the key proteins, Blimp1, Nanos, and Dead end1.
Yumiko Saga
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-07-28
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  18     ISSN:  0959-437X     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-10-22     Completed Date:  2009-01-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  England    
Other Details:
Languages:  eng     Pagination:  337-41     Citation Subset:  IM    
Division of Mammalian Development, National Institute of Genetics, Graduate University for Advanced Studies (SOKENDAI), Yata 1111, Mishima, Shizuoka 411-8540, Japan.
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MeSH Terms
Body Patterning / physiology
Carrier Proteins / genetics,  physiology
Cell Movement / physiology
Embryonic Development / genetics,  physiology*
Germ Cells / growth & development*
Models, Biological
Neoplasm Proteins / genetics,  physiology
Proto-Oncogene Proteins c-kit / genetics,  physiology
RNA-Binding Proteins / genetics,  physiology
Sex Differentiation / genetics,  physiology
Signal Transduction / genetics
Reg. No./Substance:
0/Carrier Proteins; 0/Dnd1 protein, mouse; 0/Nanos2 protein, mouse; 0/Nanos3 protein, mouse; 0/Neoplasm Proteins; 0/RNA-Binding Proteins; EC Proteins c-kit

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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