Document Detail

Mouse RanBPM is a partner gene to a germline specific RNA helicase, mouse vasa homolog protein.
MedLine Citation:
PMID:  14648869     Owner:  NLM     Status:  MEDLINE    
Germ cell-specific ATP-dependent RNA helicase, the product of the mouse vasa homolog (Mvh), has been shown to play an essential role in the development of the male germ cell. In male Mvh knockout mice, premeiotic germ cells arrest at the zygotene stage. To investigate the role of MVH protein in the progression of meiosis, we searched for genes encoding partners that interact with MVH in testicular germ cells. Using the yeast two-hybrid system, we found that MVH interacts with mouse RanBPM, a Ran-GTP binding protein involved in microtubule nucleation. RanBPM is predominantly expressed in the testis, especially in maturating spermatocytes. Within the cell, RanBPM and MVH are closely associated with perinuclear RNA-protein complexes and chromatoid bodies. The interaction of MVH with RanBPM points to a functional relationship between translational regulation and the microtubule nucleation during meiosis. Mol. Reprod. Dev. 66: 1-7, 2004.
Norito Shibata; Naoki Tsunekawa; Shino Okamoto-Ito; Ryuko Akasu; Ako Tokumasu; Toshiaki Noce
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular reproduction and development     Volume:  67     ISSN:  1040-452X     ISO Abbreviation:  Mol. Reprod. Dev.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-07-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8903333     Medline TA:  Mol Reprod Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Wiley-Liss, Inc.
Laboratory of Reproductive Biology, Mitsubishi Kasei Institute of Life Sciences, Minami-ooya, Machida-shi, Tokyo, Japan.
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MeSH Terms
Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Cytoskeletal Proteins
DEAD-box RNA Helicases
Germ Cells / enzymology*
In Situ Hybridization
Meiosis / physiology*
Mice, Knockout
Microtubules / metabolism
Molecular Sequence Data
Nuclear Proteins / chemistry,  genetics*,  metabolism*
RNA Helicases / genetics*,  metabolism*
Spermatogenesis / physiology
Testis / cytology,  metabolism
Tissue Distribution
Two-Hybrid System Techniques
ran GTP-Binding Protein / chemistry,  genetics*,  metabolism*
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Cytoskeletal Proteins; 0/Nuclear Proteins; 0/Ran binding protein 9; EC 2.7.7.-/RNA Helicases; EC 3.6.1.-/DEAD-box RNA Helicases; EC 3.6.1.-/Ddx4 protein, mouse; EC GTP-Binding Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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