Document Detail

Mouse models for studies of retinal degeneration and diseases.
MedLine Citation:
PMID:  23150358     Owner:  NLM     Status:  MEDLINE    
Mouse models, with their well-developed genetics and similarity to human physiology and anatomy, serve as powerful tools with which to investigate the etiology of human retinal degeneration. Mutant mice also provide reproducible, experimental systems for elucidating pathways of normal development and function. Here, I describe the tools used in the discoveries of many retinal degeneration models, including indirect ophthalmoscopy (to look at the fundus appearance), fundus photography and fluorescein angiography (to document the fundus appearance), electroretinography (to check retinal function), as well as the heritability test (for genetic characterization).
Bo Chang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  935     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-04-17     Revised Date:  2013-12-17    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  27-39     Citation Subset:  IM    
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MeSH Terms
Disease Models, Animal*
Electroretinography / methods
Fluorescein Angiography / methods
Fundus Oculi
Genetic Testing / methods
Mice* / anatomy & histology,  genetics,  physiology
Ophthalmoscopy / methods
Retina / metabolism,  pathology*,  physiopathology*
Retinal Degeneration / genetics,  pathology*,  physiopathology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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